ROCK2

Rho-associated, coiled-coil containing protein kinase 2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II
External IDs	MGI: 107926 HomoloGene: 21010 GeneCards: 9475
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • structural molecule activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • Rho GTPase binding • poly(A) RNA binding • ATP binding • Rho-dependent protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • centrosome • membrane • plasma membrane • microtubule organizing center • cytoplasmic ribonucleoprotein granule • cytoskeleton • cell nucleus • intracellular Biological process • smooth muscle contraction • positive regulation of protein phosphorylation • intracellular signal transduction • regulation of actin cytoskeleton organization • centrosome duplication • phosphorylation • rhythmic process • ephrin receptor signaling pathway • cellular response to testosterone stimulus • small GTPase mediated signal transduction • cytokinesis • positive regulation of centrosome duplication • regulation of stress fiber assembly • axon guidance • regulation of cell motility • positive regulation of endothelial cell migration • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • positive regulation of gene expression • regulation of cell adhesion • regulation of circadian rhythm • Rho protein signal transduction • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • cortical actin cytoskeleton organization • regulation of establishment of endothelial barrier • actin cytoskeleton organization • establishment of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9475	19878
Ensembl	ENSG00000134318	ENSMUSG00000020580
UniProt	O75116 C9JFJ0	P70336
RefSeq (mRNA)	XM_011510417 NM_004850 XM_005246190	NM_009072 XM_006515019 XM_006515020
RefSeq (protein)	NP_004841.2	NP_033098.2
Location (UCSC)	Chr 2: 11.18 – 11.35 Mb	Chr 12: 16.89 – 16.99 Mb
PubMed search
Wikidata

View/Edit Human

View/Edit Mouse

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. ^[1]

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

References

1. "Entrez Gene: Rho associated coiled-coil containing protein kinase 2". Retrieved 2016-04-21.

Further reading

• Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry 41 (28): 8948–53. PMID 12102637.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.