RPH3AL

Rabphilin 3A-like (without C2 domains)
Identifiers
Symbols	RPH3AL ; NOC2
External IDs	OMIM: 604881 MGI: 1923492 HomoloGene: 5078 GeneCards: RPH3AL Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • cytoskeletal protein binding • Rab GTPase binding • syntaxin binding • LIM domain binding • clathrin binding Cellular component • cytoplasm • plasma membrane • transport vesicle membrane • secretory granule membrane Biological process • intracellular protein transport • exocytosis • synaptic vesicle exocytosis • regulation of calcium ion-dependent exocytosis • response to drug • glucose homeostasis • negative regulation of G-protein coupled receptor protein signaling pathway • calcium ion-dependent exocytosis of neurotransmitter • positive regulation of protein secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9501	380714
Ensembl	ENSG00000181031	ENSMUSG00000020847
UniProt	Q9UNE2	Q768S4
RefSeq (mRNA)	NM_001190411	NM_001291159
RefSeq (protein)	NP_001177340	NP_001278088
Location (UCSC)	Chr 17: 0.21 – 0.39 Mb	Chr 11: 75.83 – 75.94 Mb
PubMed search

Rab effector Noc2 is a protein that in humans is encoded by the RPH3AL gene.^[1][2]

Interactions

RPH3AL has been shown to interact with RAB27A.^[3][4]

References

1. Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C (Aug 1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus". Genomics 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
2. "Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains)".
3. Cheviet, Séverine; Coppola Thierry; Haynes Lee P; Burgoyne Robert D; Regazzi Romano (Jan 2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. (United States) 18 (1): 117–26. doi:10.1210/me.2003-0300. ISSN 0888-8809. PMID 14593078.
4. Fukuda, Mitsunori (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. (United States) 278 (17): 15373–80. doi:10.1074/jbc.M212341200. ISSN 0021-9258. PMID 12578829.

Further reading

• Kotake K, Ozaki N, Mizuta M, et al. (1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells". J. Biol. Chem. 272 (47): 29407–10. doi:10.1074/jbc.272.47.29407. PMID 9367993.
• Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
• Haynes LP, Evans GJ, Morgan A, Burgoyne RD (2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells". J. Biol. Chem. 276 (13): 9726–32. doi:10.1074/jbc.M006959200. PMID 11134008.
• Goi T, Takeuchi K, Katayama K, et al. (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers". Oncol. Rep. 9 (6): 1189–92. doi:10.3892/or.9.6.1189. PMID 12375017.
• Milkereit P, Strauss D, Bassler J, et al. (2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits". J. Biol. Chem. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
• Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb Critical Region Allows Genotypic Differentiation between Isolated Lissencephaly, Miller-Dieker Syndrome, and Other Phenotypes Secondary to Deletions of 17p13.3". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
• Cheviet S, Coppola T, Haynes LP, et al. (2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis". Mol. Endocrinol. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Manabe S, Nishimura N, Yamamoto Y, et al. (2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells". Biochem. Biophys. Res. Commun. 316 (1): 218–25. doi:10.1016/j.bbrc.2004.02.026. PMID 15003533.
• Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• 1. Katkoori VR, Jia X, Chatla C, Kumar S, Ponnazhagan S, Callens T, Messiaen L, Grizzle WE, Manne U. (2008). "Clinical significance of a novel single nucleotide polymorphism in the 5′ untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma". Frontiers in Bioscience 13 (1): 1050–1061. doi:10.2741/2742. PMC 2667692. PMID 17981610. horizontal tab character in |author= at position 3 (help)