RPL19

Ribosomal protein L19
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPL19 ; L19
External IDs	OMIM: 180466 MGI: 3644244 HomoloGene: 68105 GeneCards: RPL19 Gene
Gene ontology Molecular function • RNA binding • structural constituent of ribosome • poly(A) RNA binding Cellular component • nucleolus • cytoplasm • cytosol • focal adhesion • membrane • cytosolic large ribosomal subunit Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cellular protein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6143	19921
Ensembl	ENSG00000108298	ENSMUSG00000017404
UniProt	P84098	P84099
RefSeq (mRNA)	NM_000981	NM_001159483
RefSeq (protein)	NP_000972	NP_001152955
Location (UCSC)	Chr 17: 39.2 – 39.2 Mb	Chr 11: 98.03 – 98.03 Mb
PubMed search

60S ribosomal protein L19 is a protein that in humans is encoded by the RPL19 gene.^[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[2]

References

1. Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.
2. "Entrez Gene: RPL19 ribosomal protein L19".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kumabe T, Sohma Y, Yamamoto T (1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19.". Nucleic Acids Res. 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220.
• Chan YL, Lin A, McNally J, et al. (1987). "The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein.". J. Biol. Chem. 262 (3): 1111–5. PMID 3542997.
• Davies B, Fried M (1995). "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region.". Genomics 25 (2): 372–80. doi:10.1016/0888-7543(95)80036-L. PMID 7789970.
• Henry JL, Coggin DL, King CR (1993). "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.". Cancer Res. 53 (6): 1403–8. PMID 8095182.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Deprez PH, Sempoux C, De Saeger C, et al. (2002). "Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration.". Clin. Sci. 103 (2): 171–7. doi:10.1042/CS20020033. PMID 12149109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bee A, Ke Y, Forootan S, et al. (2006). "Ribosomal protein l19 is a prognostic marker for human prostate cancer.". Clin. Cancer Res. 12 (7 Pt 1): 2061–5. doi:10.1158/1078-0432.CCR-05-2445. PMID 16609016.
• Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.". BMC Genomics 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.