RPL22

Ribosomal protein L22
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPL22 ; EAP; HBP15; HBP15/L22; L22
External IDs	OMIM: 180474 MGI: 99262 HomoloGene: 37378 GeneCards: RPL22 Gene
Gene ontology Molecular function • RNA binding • structural constituent of ribosome • protein binding • heparin binding • poly(A) RNA binding Cellular component • nucleus • cytoplasm • cytosol • focal adhesion • cytosolic large ribosomal subunit • ribonucleoprotein complex • extracellular exosome Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • cytoplasmic translation • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cellular protein metabolic process • alpha-beta T cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6146	19934
Ensembl	ENSG00000116251	ENSMUSG00000028936
UniProt	P35268	P67984
RefSeq (mRNA)	NM_000983	NM_001277113
RefSeq (protein)	NP_000974	NP_001264042
Location (UCSC)	Chr 1: 6.18 – 6.21 Mb	Chr 4: 152.33 – 152.33 Mb
PubMed search

60S ribosomal protein L22 is a protein that in humans is encoded by the RPL22 gene.^[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.^[2]

References

1. Nucifora G, Begy CR, Erickson P, Drabkin HA, Rowley JD (Sep 1993). "The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1". Proc Natl Acad Sci U S A 90 (16): 7784–8. doi:10.1073/pnas.90.16.7784. PMC 47227. PMID 8395054.
2. "Entrez Gene: RPL22 ribosomal protein L22".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Toczyski DP, Steitz JA (1991). "EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)". EMBO J. 10 (2): 459–66. PMC 452667. PMID 1846807.
• Fujita Y, Okamoto T, Noshiro M, et al. (1994). "A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22". Biochem. Biophys. Res. Commun. 199 (2): 706–13. doi:10.1006/bbrc.1994.1286. PMID 8135813.
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Le S, Sternglanz R, Greider CW (2000). "Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA". Mol. Biol. Cell 11 (3): 999–1010. doi:10.1091/mbc.11.3.999. PMC 14826. PMID 10712515.
• Shu-Nu C, Lin CH, Lin A (2000). "An acidic amino acid cluster regulates the nucleolar localization and ribosome assembly of human ribosomal protein L22". FEBS Lett. 484 (1): 22–8. doi:10.1016/S0014-5793(00)02118-9. PMID 11056215.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Chen KC, Chiang HS, Fang CL (2005). "EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients". Urol. Int. 74 (3): 280–2. doi:10.1159/000083565. PMID 15812220.
• Fok V, Mitton-Fry RM, Grech A, Steitz JA (2006). "Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22". RNA 12 (5): 872–82. doi:10.1261/rna.2339606. PMC 1440895. PMID 16556938.
• Nakao K, Mochiki M, Nibu K, et al. (2006). "Analysis of prognostic factors of nasopharyngeal carcinoma: impact of in situ hybridization for Epstein-Barr virus encoded small RNA 1". Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 134 (4): 639–45. doi:10.1016/j.otohns.2005.11.022. PMID 16564389.