60S ribosomal protein L41

Ribosomal protein L41
Available structures PDB Human UniProt search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPL41 ; L41
External IDs	OMIM: 613315 GeneCards: RPL41 Gene
Gene ontology Molecular function • RNA binding • structural constituent of ribosome Cellular component • cytosol • cytosolic large ribosomal subunit Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6171	n/a
Ensembl	ENSG00000229117	n/a
UniProt	P62945	n/a
RefSeq (mRNA)	NM_001035267	n/a
RefSeq (protein)	NP_001030344	n/a
Location (UCSC)	Chr 12: 56.12 – 56.12 Mb	n/a
PubMed search		n/a

60S ribosomal protein L41 is a protein that in humans is encoded by the RPL41 gene.^[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

References

1. Klaudiny J, von der Kammer H, Scheit KH (Oct 1992). "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41". Biochem Biophys Res Commun 187 (2): 901–6. doi:10.1016/0006-291X(92)91282-U. PMID 1326959.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
3. "Entrez Gene: RPL41 ribosomal protein L41".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kato S, Sekine S, Oh SW; et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Lee JH, Kim JM, Kim MS; et al. (1997). "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII.". Biochem. Biophys. Res. Commun. 238 (2): 462–7. doi:10.1006/bbrc.1997.7317. PMID 9299532.
• Go H, Miyado K, Taniguchi S (1999). "Genomic structure of the human ribosomal protein L41 gene.". Biochem. Mol. Biol. Int. 46 (6): 1227–31. doi:10.1080/15216549800204792. PMID 9891856.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Ahn BH, Kim TH, Bae YS (2002). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins.". Mol. Cells 12 (2): 158–63. PMID 11710515.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.