RPL6

Ribosomal protein L6
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPL6 ; L6; SHUJUN-2; TAXREB107; TXREB1
External IDs	OMIM: 603703 HomoloGene: 31001 GeneCards: RPL6 Gene
Gene ontology Molecular function • DNA binding • RNA binding • structural constituent of ribosome • poly(A) RNA binding Cellular component • nucleus • cytosol • focal adhesion • membrane • cytosolic large ribosomal subunit • cytoplasmic ribonucleoprotein granule Biological process • ribosomal large subunit assembly • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • cytoplasmic translation • regulation of transcription, DNA-templated • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cellular protein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6128	19988
Ensembl	ENSG00000089009	ENSMUSG00000029614
UniProt	Q02878	P47911
RefSeq (mRNA)	NM_000970	NM_011290
RefSeq (protein)	NP_000961	NP_035420
Location (UCSC)	Chr 12: 112.41 – 112.42 Mb	Chr 5: 121.2 – 121.21 Mb
PubMed search

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.^[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6E family of ribosomal proteins. It is located in the cytoplasm. The protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and it has been suggested that the protein may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3]

Interactions

RPL6 has been shown to interact with Basic fibroblast growth factor.^[4]

References

1. Zaman GJ (May 1993). "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6". Nucleic Acids Res 21 (7): 1673. doi:10.1093/nar/21.7.1673. PMC 309386. PMID 8479925.
2. Morita T, Sato T, Nyunoya H, Tsujimoto A, Takahara J, Irino S, Shimotohno K (Apr 1993). "Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I". AIDS Res Hum Retroviruses 9 (2): 115–21. doi:10.1089/aid.1993.9.115. PMID 8457378.
3. "Entrez Gene: RPL6 ribosomal protein L6".
4. Shen, B; Arese M; Gualandris A; Rifkin D B (Nov 1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochem. Biophys. Res. Commun. (UNITED STATES) 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. ISSN 0006-291X. PMID 9826564.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Nika H, Hultin T (1984). "Location of the sulfhydryl groups involved in disulfide interaction between the neighboring proteins L6 and L29 in mammalian ribosomes. S-cleavage of the cyanylated proteins in polyacrylamide gels after separation by dodecylsulfate gel electrophoresis". Eur. J. Biochem. 142 (3): 521–6. doi:10.1111/j.1432-1033.1984.tb08316.x. PMID 6468376.
• Todokoro K, Ulbrich N, Chan YL, Wool IG (1981). "Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid". J. Biol. Chem. 256 (14): 7207–12. PMID 7251593.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Ohta K, Endo T, Gunji K, Onaya T (1994). "Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues". J. Mol. Endocrinol. 12 (1): 85–92. doi:10.1677/jme.0.0120085. PMID 8185817.
• Monk S, Sakuntabhai A, Carter SA, et al. (1998). "Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region". Am. J. Hum. Genet. 62 (4): 890–903. doi:10.1086/301794. PMC 1377034. PMID 9529352.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Shen B, Arese M, Gualandris A, Rifkin DB (1998). "Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107". Biochem. Biophys. Res. Commun. 252 (2): 524–8. doi:10.1006/bbrc.1998.9677. PMID 9826564.
• Ye Z, Connor JR (2000). "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochem. Biophys. Res. Commun. 275 (1): 223–7. doi:10.1006/bbrc.2000.3282. PMID 10944468.
• Kenmochi N, Yoshihama M, Higa S, Tanaka T (2000). "The human ribosomal protein L6 gene in a critical region for Noonan syndrome". J. Hum. Genet. 45 (5): 290–3. doi:10.1007/s100380070018. PMID 11043511.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Du JP, Jin XH, Shi YQ, et al. (2003). "[Differential expression of RPL6/Taxreb107 in drug resistant gastric cancer cell line SGC7901/ADR and its correlation with multiple-drug resistance]". Zhonghua Zhong Liu Za Zhi 25 (1): 21–5. PMID 12678981.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.