RPLP0

Ribosomal protein, large, P0
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPLP0 ; L10E; LP0; P0; PRLP0; RPP0
External IDs OMIM: 180510 MGI: 88066 HomoloGene: 6517 GeneCards: RPLP0 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6175 11837
Ensembl ENSG00000089157 ENSMUSG00000067274
UniProt P05388 P14869
RefSeq (mRNA) NM_001002 NM_007475
RefSeq (protein) NP_000993 NP_031501
Location (UCSC) Chr 12:
120.2 – 120.2 Mb
Chr 5:
115.56 – 115.56 Mb
PubMed search

60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[2]

References

  1. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  2. 1 2 "Entrez Gene: RPLP0 ribosomal protein, large, P0".

Further reading


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