RPS12

Ribosomal protein S12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPS12 ; S12
External IDs	OMIM: 603660 MGI: 98105 HomoloGene: 110750 GeneCards: RPS12 Gene
Gene ontology Molecular function • structural constituent of ribosome • poly(A) RNA binding Cellular component • cytosol • membrane • cytosolic small ribosomal subunit Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6206	20042
Ensembl	ENSG00000112306	ENSMUSG00000061983
UniProt	P25398	Q6ZWZ6
RefSeq (mRNA)	NM_001016	NM_011295
RefSeq (protein)	NP_001007	NP_035425
Location (UCSC)	Chr 6: 132.81 – 132.82 Mb	Chr 10: 23.79 – 23.79 Mb
PubMed search

40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.^[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

References

1. Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC 328500. PMID 1861993.
2. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
3. "Entrez Gene: RPS12 ribosomal protein S12".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Pogue-Geile K, Geiser JR, Shu M, et al. (1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. PMC 361167. PMID 1712897.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Cheng Q, Lau WM, Chew SH, et al. (2002). "Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix". Br. J. Cancer 86 (2): 274–81. doi:10.1038/sj.bjc.6600038. PMC 2375172. PMID 11870519.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.