RPS14

Ribosomal protein S14
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPS14 ; EMTB; S14
External IDs	OMIM: 130620 MGI: 98107 HomoloGene: 90926 GeneCards: RPS14 Gene
Gene ontology Molecular function • RNA binding • structural constituent of ribosome • protein binding • poly(A) RNA binding • translation regulator activity • mRNA 5'-UTR binding • small ribosomal subunit rRNA binding Cellular component • nucleolus • cytoplasm • mitochondrion • cytosol • focal adhesion • membrane • cytosolic small ribosomal subunit • extracellular exosome Biological process • ribosomal small subunit assembly • negative regulation of transcription from RNA polymerase II promoter • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • translation • translational initiation • translational elongation • translational termination • regulation of translation • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • erythrocyte differentiation • maturation of SSU-rRNA • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6208	20044
Ensembl	ENSG00000164587	ENSMUSG00000024608
UniProt	P62263	P62264
RefSeq (mRNA)	NM_001025070	NM_020600
RefSeq (protein)	NP_001020241	NP_065625
Location (UCSC)	Chr 5: 150.44 – 150.45 Mb	Chr 18: 60.77 – 60.78 Mb
PubMed search

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.^[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3]

References

1. Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol 6 (8): 2774–83. PMC 367844. PMID 3785212.
2. Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol 12 (4): 1680–6. PMC 369611. PMID 1549121.
3. "Entrez Gene: RPS14 ribosomal protein S14".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Chen IT, Dixit A, Rhoads DD, Roufa DJ (1986). "Homologous ribosomal proteins in bacteria, yeast, and humans.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6907–11. doi:10.1073/pnas.83.18.6907. PMC 386619. PMID 3529092.
• Dana S, Wasmuth JJ (1983). "Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.". Mol. Cell. Biol. 2 (10): 1220–8. PMC 369921. PMID 7177110.
• Tasheva ES, Roufa DJ (1995). "Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14.". Genes Dev. 9 (3): 304–16. doi:10.1101/gad.9.3.304. PMID 7867928.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Martin-Nieto J, Roufa DJ (1997). "Functional analysis of human RPS14 null alleles.". J. Cell. Sci. 110 (8): 955–63. PMID 9152021.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.