RPS15

Ribosomal protein S15
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPS15 ; RIG; S15
External IDs	OMIM: 180535 MGI: 3647234 HomoloGene: 110643 GeneCards: RPS15 Gene
Gene ontology Molecular function • DNA binding • structural constituent of ribosome • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • focal adhesion • membrane • cytosolic small ribosomal subunit Biological process • ribosomal small subunit assembly • ribosomal small subunit export from nucleus • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • osteoblast differentiation • rRNA processing • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • ribosomal small subunit biogenesis • cellular protein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6209	20054
Ensembl	ENSG00000115268	ENSMUSG00000063457
UniProt	P62841	P62843
RefSeq (mRNA)	NM_001018	NM_009091
RefSeq (protein)	NP_001009	NP_033117
Location (UCSC)	Chr 19: 1.44 – 1.44 Mb	Chr 10: 80.29 – 80.29 Mb
PubMed search

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.^[1][2]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[2]

References

1. Shiga K, Yamamoto H, Okamoto H (Jun 1990). "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes". Proc Natl Acad Sci U S A 87 (9): 3594–8. doi:10.1073/pnas.87.9.3594. PMC 53948. PMID 2159154.
2. "Entrez Gene: RPS15 ribosomal protein S15".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kitagawa M, Takasawa S, Kikuchi N, et al. (1991). "rig encodes ribosomal protein S15. The primary structure of mammalian ribosomal protein S15". FEBS Lett. 283 (2): 210–4. doi:10.1016/0014-5793(91)80590-Y. PMID 2044758.
• Inoue C, Shiga K, Takasawa S, et al. (1987). "Evolutionary conservation of the insulinoma gene rig and its possible function". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6659–62. doi:10.1073/pnas.84.19.6659. PMC 299142. PMID 2821540.
• Marion MJ, Marion C (1988). "Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin". FEBS Lett. 232 (2): 281–5. doi:10.1016/0014-5793(88)80753-1. PMID 3378620.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.