RPS3

Ribosomal protein S3

PDB rendering based on 1wh9.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RPS3 ; S3
External IDs OMIM: 600454 MGI: 1350917 HomoloGene: 779 GeneCards: RPS3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6188 27050
Ensembl ENSG00000149273 ENSMUSG00000030744
UniProt P23396 P62908
RefSeq (mRNA) NM_001005 NM_012052
RefSeq (protein) NP_000996 NP_036182
Location (UCSC) Chr 11:
75.4 – 75.42 Mb
Chr 7:
99.48 – 99.48 Mb
PubMed search

40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.[1][2][3]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

References

  1. Pogue-Geile K, Geiser JR, Shu M, Miller C, Wool IG, Meisler AI, Pipas JM (Aug 1991). "Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein". Mol. Cell. Biol. 11 (8): 3842–9. PMC 361167. PMID 1712897.
  2. Polakiewicz RD, Munroe DJ, Sait SN, Tycowski KT, Nowak NJ, Shows TB, Housman DE, Page DC (Jul 1995). "Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5". Genomics 25 (2): 577–80. doi:10.1016/0888-7543(95)80063-R. PMID 7789996.
  3. 1 2 "Entrez Gene: RPS3 ribosomal protein S3".

Further reading


This article is issued from Wikipedia - version of the Sunday, August 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.