RPS6KA6

Ribosomal protein S6 kinase, 90kDa, polypeptide 6
Identifiers
Symbols	RPS6KA6 ; PP90RSK4; RSK4
External IDs	OMIM: 300303 HomoloGene: 22816 IUPHAR: 1530 GeneCards: RPS6KA6 Gene
EC number	2.7.11.1
Gene ontology Molecular function • magnesium ion binding • protein kinase activity • ribosomal protein S6 kinase activity • ATP binding Cellular component • nucleus • nucleoplasm • nucleoplasm • nucleolus • mitochondrion • cytosol Biological process • regulation of translation • protein phosphorylation • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • signal transduction • synaptic transmission • axon guidance • central nervous system development • negative regulation of embryonic development • negative regulation of ERK1 and ERK2 cascade • negative regulation of mesoderm development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27330	67071
Ensembl	ENSG00000072133	ENSMUSG00000025665
UniProt	Q9UK32	Q7TPS0
RefSeq (mRNA)	NM_014496	NM_025949
RefSeq (protein)	NP_055311	NP_080225
Location (UCSC)	Chr X: 84.06 – 84.19 Mb	Chr X: 111.39 – 111.54 Mb
PubMed search

Ribosomal protein S6 kinase, 90kDa, polypeptide 6 is a protein in humans that is encoded by the RPS6KA6 gene. ^[1]

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].

References

1. "Entrez Gene: Ribosomal protein S6 kinase, 90kDa, polypeptide 6". Retrieved 2013-01-15.

Further reading