RPS7

Ribosomal protein S7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V6X​, 5AJ0​
Identifiers
Symbols	RPS7 ; DBA8; S7
External IDs	OMIM: 603658 MGI: 1333818 HomoloGene: 107159 GeneCards: RPS7 Gene
EC number	3.6.5.3
Gene ontology Molecular function • RNA binding • structural constituent of ribosome • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleolus • cytoplasm • microtubule organizing center • cytosol • ribosome • focal adhesion • membrane • cytosolic small ribosomal subunit • ribonucleoprotein complex • 90S preribosome • small-subunit processome • extracellular exosome Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • neural tube closure • rRNA processing • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • gene expression • viral process • viral life cycle • viral transcription • cell differentiation • ribosomal small subunit biogenesis • cellular protein metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6201	20115
Ensembl	ENSG00000171863	ENSMUSG00000061477
UniProt	P62081	P62082
RefSeq (mRNA)	NM_001011	NM_011300
RefSeq (protein)	NP_001002	NP_035430
Location (UCSC)	Chr 2: 3.58 – 3.58 Mb	Chr 12: 28.63 – 28.64 Mb
PubMed search

40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.^[1][2][3]

In eukaryotes, ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

References

1. Annilo T, Laan M, Stahl J, Metspalu A (Jan 1996). "The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25". Gene 165 (2): 297–302. doi:10.1016/0378-1119(95)00576-R. PMID 8522193.
2. Gorbea C, Taillandier D, Rechsteiner M (Feb 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J Biol Chem 275 (2): 875–82. doi:10.1074/jbc.275.2.875. PMID 10625621.
3. "Entrez Gene: RPS7 ribosomal protein S7".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID 8318536.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515.
• Jäkel S, Mingot JM, Schwarzmaier P, et al. (2002). "Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains". EMBO J. 21 (3): 377–86. doi:10.1093/emboj/21.3.377. PMC 125346. PMID 11823430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Tompkins V, Hagen J, Zediak VP, Quelle DE (2006). "Identification of novel ARF binding proteins by two-hybrid screening". Cell Cycle 5 (6): 641–6. doi:10.4161/cc.5.6.2560. PMID 16582619.
• Chen D, Zhang Z, Li M, et al. (2007). "Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function". Oncogene 26 (35): 5029–37. doi:10.1038/sj.onc.1210327. PMID 17310983.