RRAGA

Ras-related GTP binding A
Identifiers
Symbols	RRAGA ; FIP-1; FIP1; RAGA
External IDs	OMIM: 612194 MGI: 1915691 HomoloGene: 68522 GeneCards: RRAGA Gene
Gene ontology Molecular function • GTPase activity • protein binding • GTP binding • ubiquitin protein ligase binding • protein homodimerization activity • protein heterodimerization activity • phosphoprotein binding Cellular component • nucleus • cytoplasm • lysosome • lysosomal membrane • Golgi apparatus • EGO complex • intracellular membrane-bounded organelle • Iml1 complex • Gtr1-Gtr2 GTPase complex Biological process • apoptotic process • cell death • cellular response to starvation • regulation of autophagy • negative regulation of autophagy • modulation by virus of host morphology or physiology • positive regulation of TOR signaling • cellular response to amino acid starvation • cellular protein localization • positive regulation of cytolysis • cellular response to amino acid stimulus • positive regulation of TORC1 signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10670	68441
Ensembl	ENSG00000155876	ENSMUSG00000070934
UniProt	Q7L523	Q80X95
RefSeq (mRNA)	NM_006570	NM_178376
RefSeq (protein)	NP_006561	NP_848463
Location (UCSC)	Chr 9: 19.05 – 19.05 Mb	Chr 4: 86.58 – 86.58 Mb
PubMed search

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.^[1][2][3]

Interactions

RRAGA has been shown to interact with NOL8^[4] and RRAGC.^[5][6]

References

1. Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
2. Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology 71 (2): 1576–82. PMC 191215. PMID 8995684.
3. "Entrez Gene: RRAGA Ras-related GTP binding A".
4. Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
6. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

Further reading

• Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Jan 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". Journal of Cell Science. 111 ( Pt 1) (1): 11–21. PMID 9394008.
• Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
• Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.