RSPO2

R-spondin 2
Identifiers
Symbols	RSPO2 ; CRISTIN2
External IDs	OMIM: 610575 HomoloGene: 18235 GeneCards: RSPO2 Gene
Gene ontology Molecular function • G-protein coupled receptor binding • receptor binding • protein binding • heparin binding Cellular component • extracellular region • extracellular space • cell surface Biological process • osteoblast differentiation • Wnt signaling pathway • bone mineralization • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • negative regulation of odontogenesis of dentin-containing tooth • lung growth • epithelial tube branching involved in lung morphogenesis • trachea cartilage morphogenesis • dopaminergic neuron differentiation • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340419	239405
Ensembl	ENSG00000147655	ENSMUSG00000051920
UniProt	Q6UXX9	Q8BFU0
RefSeq (mRNA)	NM_001282863	NM_172815
RefSeq (protein)	NP_001269792	NP_766403
Location (UCSC)	Chr 8: 107.9 – 108.08 Mb	Chr 15: 43.02 – 43.17 Mb
PubMed search

R-spondin 2 also known as roof plate-specific spondin-2 is a protein that in humans that is encoded by the RSPO2 gene.^[1]

R-spondin 2 synergizes with Wnt to activate beta-catenin.^[2][3] RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.^[4]

In dogs, the Rspo2 gene determines hair growth.^[5]

References

1. "Entrez Gene: R-spondin 2".
2. Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD (January 2006). "R-Spondin proteins: a novel link to beta-catenin activation". Cell Cycle 5 (1): 23–6. doi:10.4161/cc.5.1.2305. PMID 16357527.
3. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (October 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Dev. Cell 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841.
4. Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK (2011). "The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal–mesenchymal interaction". Developmental Biology 352 (1): 1–13. doi:10.1016/j.ydbio.2011.01.004. PMC 3089906. PMID 21237142.
5. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA (October 2009). "Coat variation in the domestic dog is governed by variants in three genes". Science 326 (5949): 150–3. doi:10.1126/science.1177808. PMC 2897713. PMID 19713490.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.