RSU1

Ras suppressor protein 1
Identifiers
Symbols	RSU1 ; RSP-1
External IDs	OMIM: 179555 MGI: 103040 HomoloGene: 7521 GeneCards: RSU1 Gene
Gene ontology Molecular function • protein binding Cellular component • cytosol • focal adhesion • extracellular exosome Biological process • signal transduction • Ras protein signal transduction • regulation of cell-substrate adhesion • positive regulation of cell-substrate adhesion • cell junction assembly • positive regulation of GTPase activity • positive regulation of neural precursor cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6251	20163
Ensembl	ENSG00000148484	ENSMUSG00000026727
UniProt	Q15404	Q9D031
RefSeq (mRNA)	NM_012425	NM_009105
RefSeq (protein)	NP_036557	NP_033131
Location (UCSC)	Chr 10: 16.59 – 16.82 Mb	Chr 2: 13.08 – 13.27 Mb
PubMed search

Ras suppressor protein 1 is a protein that in humans is encoded by the RSU1 gene.^[1][2]

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors.^[2] RSU-1 has also been seen to act as a structural protein in integrin-mediated focal-adhesion complexes. It bind strongly to the protein PINCH.

References

1. Tsuda T, Cutler ML (Feb 1994). "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10". Genomics 18 (2): 461–2. doi:10.1006/geno.1993.1503. PMID 8288261.
2. "Entrez Gene: RSU1 Ras suppressor protein 1".

Further reading

• Cutler ML, Bassin RH, Zanoni L, Talbot N (1992). "Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation". Mol. Cell. Biol. 12 (9): 3750–6. PMC 360236. PMID 1508180.
• Tsuda T, Marinetti MR, Masuelli L, Cutler ML (1995). "The Ras suppressor RSU-1 localizes to 10p13 and its expression in the U251 glioblastoma cell line correlates with a decrease in growth rate and tumorigenic potential". Oncogene 11 (2): 397–403. PMID 7624154.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Masuelli L, Cutler ML (1996). "Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation". Mol. Cell. Biol. 16 (10): 5466–76. PMC 231547. PMID 8816460.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chunduru S, Kawami H, Gullick R, et al. (2003). "Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas". J. Neurooncol. 60 (3): 201–11. doi:10.1023/A:1021130620178. PMID 12510772.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dougherty GW, Chopp T, Qi SM, Cutler ML (2005). "The Ras suppressor Rsu-1 binds to the LIM 5 domain of the adaptor protein PINCH1 and participates in adhesion-related functions". Exp. Cell Res. 306 (1): 168–79. doi:10.1016/j.yexcr.2005.01.025. PMID 15878342.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.