Ramanujan Hegde

Manu Hegde
Born Ramanujan Shankar Hegde
Fields Biochemistry
Institutions
Alma mater
Thesis The regulation of protein translocation at the endoplasmic reticulum (1998)
Doctoral advisor Vishwanath R. Lingappa[2]
Notable awards

Website

Ramanujan Shankar Hegde FRS[3] is a Group Leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge.[4]

Education

Hegde was educated at the University of Chicago[1] and the University of California, San Francisco where he was awarded a PhD in 1998 for research on protein targeting in the endoplasmic reticulum supervised by Vishwanath R. Lingappa.[2][1]

Research

Hegde's research investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases.[3]

His laboratory have discovered a widely conserved signalling pathway needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Manu’s work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialized pathways to identify these wayward proteins and target them for destruction.[3]

As of 2016, according to Google Scholar his most cited research has been published in Science[5] and Nature.[6] His research has been funded by the Medical Research Council.[7]

Awards and honours

Hegde was awarded the R.R. Bensley award in Cell Biology in 2008 and elected a member of the European Molecular Biology Organisation (EMBO) in 2013.[3] He was also elected a Fellow of the Royal Society (FRS) in 2016.[3]

References

  1. 1 2 3 Sedwick, Caitlin (2010). "Ramanujan Hegde: The prion puzzle and protein translocation". The Journal of Cell Biology 191 (7): 1222–1223. doi:10.1083/jcb.1917pi.
  2. 1 2 Hegde, Ramanujan Shankar (1998). The regulation of protein translocation at the endoplasmic reticulum (PhD thesis). University of California, San Francisco. OCLC 50795524.
  3. 1 2 3 4 5 6 "Dr Ramanujan Hegde FRS". London: The Royal Society. Archived from the original on 2016-04-29. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
  4. ↑ "Ramanujan Hegde MRC Laboratory of Molecular Biology: Membrane protein biosynthesis and quality control". Cambridge: cam.ac.uk. Archived from the original on 2016-04-13.
  5. ↑ Hegde, R. S. (1998). "A Transmembrane Form of the Prion Protein in Neurodegenerative Disease". Science 279 (5352): 827–834. doi:10.1126/science.279.5352.827. PMID 9452375.
  6. ↑ Lingappa, Vishwanath R.; Hegde, Ramanujan S.; Tremblay, Patrick; Groth, Darlene; DeArmond, Stephen J.; Prusiner, Stanley B. (1999). "Transmissible and genetic prion diseases share a common pathway of neurodegeneration". Nature 402 (6763): 822–826. doi:10.1038/45574. PMID 10617204.
  7. ↑ "UK Government Grants awarded to Ramanujan Hegde". Swindon: Research Councils UK. Archived from the original on 2016-05-04.
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