Hymenolepis diminuta

Hymenolepis diminuta
Scientific classification
Kingdom: Animalia
Phylum: Platyhelminthes
Class: Cestoda
Order: Cyclophyllidea
Family: Hymenolepididae
Genus: Hymenolepis
Species: H. diminuta
Binomial name
Hymenolepis diminuta
(Rudolphi, 1819)
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Hymenolepis diminuta, also known as rat tapeworm, is a species of Hymenolepis tapeworm that causes hymenolepiasis. It has slightly bigger eggs and proglottids than H. nana and infects mammals using insects as intermediate hosts. The adult structure is 20 to 60 cm long and the mature proglottid is similar to that of H. nana, except it is larger.

H. diminuta is prevalent worldwide, but only a few hundred human cases have been reported.[1][2][3] Few cases have ever been reported in Australia, United States, Spain, and Italy. In countries such as Malaysia, Thailand, Jamaica, Indonesia, the prevalence is higher.[4][5][6]

Life cycle

The cycle begins as arthropods ingest the eggs. Arthropods are then able to act as the intermediate host. When ingested, the eggs develop into cysticercoids. As shown in the CDC life cycle, oncospheres hatch and then penetrate the intestinal wall.[7] Rodents can become infected when they eat arthropods. Humans, especially children, can ingest the arthropods as well and therefore become infected via the same mechanism. Rodents, especially rats, are definitive hosts and natural reservoirs of H. diminuta. The intermediate hosts are the coprophilic arthropods (fleas, lepidoptera, and coleoptera). As the definitive host (rats) eats an infected arthropod, cysticercoids present in the body cavity transform into the adult worm. The resulting eggs are then passed through the stool. In recent findings, beetle-to-beetle transmission of H. diminuta can be seen via the feces. Additionally, more infections occur due to this mechanism of egg dispersal.[8]

Prevalence

H. diminuta infection in humans is rare, typically occurring in isolated cases. As such, several studies of H. diminuta exist as case reports describing a single affected individual.

In rural Devghar, India, a place heavily infested with rodents and cockroaches, H. diminuta eggs were found in a 12-year-old girl living in a small village.[9]

In an urban area of Rome, a 2-year-old boy was also infected by H. diminuta. However, in this instance, investigators found no evidence of rodent or other possible sources of infection in the places habitually occupied by the affected boy.[5]

In 1989, a child from St. James Parish, Jamaica was the subject of the first documented case of H. diminuta occurring in Jamaica, West Indies.[10]

Influence on host behavior

In a behavioral study of the beetle Tenebrio molitor with cysticercoids of the rat tapeworm H. diminuta, findings suggested that the parasite impairs a beetle's ability to conceal itself. The study followed a rat and a beetle infected with the parasite. Infected beetles were slower than the control group; however, they still maintained the same learning level. In the initial phase of infection, the beetle was in high stress. As time progressed, this did not worsen their ability to learn. Overall, the training experiment portrayed that infected beetles were unable to hide from the rat, illustrating the high impact the parasite had on its host, the beetle.[11]

Role in human diseases

H. diminuta is often asymptomatic. However, abdominal pain, irritability, itching, and eosinophilia are among the existing symptoms in a few of the reported cases.

H. diminuta has been cited as a possible candidate species for helminthic therapy, i.e. the controlled use of live organism parasites for the prevention and control of diseases of modern living. These diseases include allergies, asthma, autoimmune diseases and autism spectrum disorders. [12]

Treatment

Since data regarding praziquantel treatment of H. diminuta is sparse, scientists have recommended that every case and treatment of H. diminuta be reported for development of protocols and parasitological purposes.[4]

A 2-year-old Italian boy affected by tuberous sclerosis was infected by H. diminuta. Due to concerns over his neurological condition, the boy was treated with niclosamide rather than praziquantel. In this case, niclosamide treatment proved to be successful.[5]

Notes

  1. ↑ Lo CT, Ayele Y, Birrie H. Helminth and snail survey in Harerge region of Ethiopia with special reference to Schistosomiasis. Ethiop Med J 1989;27:73-83.
  2. ↑ McMillan B, Kelly A, Walkar JC. Prevalence of Hymenolepis diminuta infection in man in the New Guinea Highlands. Trop Geogr Med 1971;23:390-2.
  3. ↑ Mercado R, Arias B. Infections by Taenia sp and other intestinal cestodos in patients of consultorios hospitals and the public sector north of Santiago de Chile (1985–1995). Bol Chil Parasitol 1995:50:80-3.
  4. 1 2 Tena D, Pιrez Simón M, Gimeno C, Pιrez Pomata MT, Illescas S, Amondarain I, et al. Human infection with Hymenolepis diminuta : Case report from Spain. J Clin Microbiol 1998;36:2375-6.
  5. 1 2 3 Marangi M, Zechini B, Fileti A, Quaranta G, Aceti A. Hymenolepis diminuta infection in a child living in the urban area of Rome, Italy. J Clin Microbiol 2003;41:3994-5.
  6. ↑ Kan SK, Kok RT, Marto S, Thomas I , Teo WW. The first report in Hymenolepis diminuta infection in Sabah, Malaysia. Trans R Soc Trop Med Hyg 1981;75:609.
  7. ↑ "CDC - DPDx - Hymenolepiasis (Life Cycles)". cdc.gov. Center for Disease Control. Hymenolepis diminuta. Retrieved 2016-04-15.
  8. ↑ Pappas, P. W., and A. J. Barley. 1999. Beetle-to-beetle transmission and dispersal of Hymenolepis diminuta (Cestoda) eggs via the feces of Tenebrio molitor. J. Parasitol. 85:384-385.
  9. ↑ Watwe S, Dardi CK. Hymenolepis diminuta in a child from rural area. Indian Journal of Pathology & Microbiology 2008; 51(1): 149-150.
  10. ↑ Cohen IP. A case report of Hymenolepis diminuta in a child in St James Parish, Jamaica. J La State Med Soc 1989;141: 23-4.
  11. ↑ Sheiman IM, Shkutin MF, Terenina NB, Gustafsson MK. A behavioral study of the beetle Tenebrio molitor infected with cysticercoids of the rat tapeworm Hymenolepis diminuta. Naturwissenschaften. 2006 Jun;93(6):305-8. Epub 2006 Mar 23.
  12. ↑ Parker W, Perkins SE, Harker M, Muehlenbein MP. A prescription for clinical immunology: the pills are available and ready for testing. A review. Curr Med Res Opin. 2012 Jul;28(7):1193-202. Epub 2012 Jun 12.
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