Renal medullary carcinoma

Renal medullary carcinoma

Location of renal medulla.
Classification and external resources
ICD-O M8319/3

Renal medullary carcinoma is a rare type of cancer that affects the kidney. It tends to be aggressive, difficult to treat, and is often metastatic at the time of diagnosis. Most individuals with this type of cancer have sickle cell trait or rarely sickle cell disease, suggesting that the sickle cell trait may be a risk factor for this type of cancer.

Classification

Renal medullary carcinoma has been termed "the seventh sickle cell nephropathy" because it is found almost exclusively in individuals with sickle cell trait or occasionally in those with sickle cell disease.[1]

Medical signs and symptoms

In a case series of 34 patients, Davis and colleagues reported the following signs and symptoms:

Other researchers have reported a palpable renal mass[2] or enlarged lymph nodes.[3]

Causes/genetics

The etiology of renal medullary carcinoma is still not completely understood. However, the majority of individuals diagnosed with this type of cancer have had sickle cell trait, in which the person carries one normal copy of the hemoglobin A gene (HbA) and one copy of the hemoglobin A gene harboring the genetic mutation found in sickle cell disease (HbS). These individuals do not have sickle cell disease but can manifest symptoms such as kidney damage over the course of their lives. The other genetic or environmental factors that contribute to the risk of renal medullary carcinoma are unknown.

Mechanism

The finding that virtually all people affected by renal medullary carcinoma carry at least one copy of the HbS mutation suggests that sickle cell trait somehow predisposes to this type of cancer.[1] The precise mechanism is unknown, however red blood cells with a sickle cell configuration have been identified in pathology specimens.[3]

Diagnosis

The diagnosis of renal medullary carcinoma is typically made after individuals with sickle cell trait present with the typical signs and symptoms outlined above, in combination with radiographic imaging (usually abdominal/pelvic CT scan) studies and ultimately surgical biopsy and pathological examination of the tumor. Findings on radiographic examination are non-specific and can reveal a mass deep within the kidney.[4] Histopathology studies show a distinctive pattern that can be distinguished from other renal tumors.[2]

Prevention

Renal medullary carcinoma is extremely rare and it is not currently possible to predict those individuals with sickle cell trait who will eventually develop this cancer. It is hoped that early detection could result in better outcomes but screening is not feasible.

Management

This cancer is typically aggressive, presents at an advanced stage when the cancer has already metastasized, and is resistant to chemotherapy. It therefore poses a significant management challenge.[5] Current treatment options include surgical resection and chemotherapy with a variety of agents, including (but not limited to) ifosfamide, etoposide, carboplatin, and topotecan.[6] A recent study looked at the use of methotrexate, vinblastine, doxorubicin, and cisplatin in 3 patients and saw a partial response and longer survival than historical reports.[7] Carboplatin, gemcitibine, and paclitaxel provided a complete response in a patient with advanced disease.[8] The role of radiation is unclear; some tumors have shown a response to radiation. Due to the apparent propensity for the tumor to spread to the central nervous system, it has been suggested that prophylactic craniospinal irradiation should be considered.[9]

Prognosis

Since the cancer most often presents at an advanced stage, prognosis is generally very poor, with median survival times of 3 months (range 1–7 months).[5] Longer survival of beyond one year was reported in one patient[6] and of up to eight years in one individual whose tumor was well circumscribed and non-metastatic at the time of diagnosis,[10] suggesting that early detection could dramatically improve survival.

Epidemiology

As of 2009, there have been approximately 120 reported cases of renal medullary carcinoma.[11] In every instance except for one, the patients were positive for cell sickling. Wilms' tumor, the most common renal tumor of childhood, is responsible for 6-7% of childhood cancer whereas all remaining primary renal tumors (among which is included renal medullary carcinoma) collectively account for less than 1% of all childhood cancer and less than 10% of primary kidney tumors in childhood.[12]

History

Renal medullary carcinoma was first described as a clinicopathologic entity in 1995.[1]

References

  1. 1 2 3 Davis, Charles J.; Mostofi, F. K.; Sesterhenn, Isabell A. (1995). "Renal Medullary Carcinoma the Seventh Sickle Cell Nephropathy". The American Journal of Surgical Pathology 19 (1): 1–11. doi:10.1097/00000478-199501000-00001. PMID 7528470.
  2. 1 2 Assad, Lina; Resetkova, Erika; Oliveira, Victor L.; Sun, Wei; Stewart, John M.; Katz, Ruth L.; Caraway, Nancy P. (2004). "Cytologic features of renal medullary carcinoma". Cancer 105 (1): 28–34. doi:10.1002/cncr.20764. PMID 15593260.
  3. 1 2 Warren, K. E.; Gidvani-Diaz, V.; Duval-Arnould, B. (1999). "Renal Medullary Carcinoma in an Adolescent with Sickle Cell Trait". Pediatrics 103 (2): E22. doi:10.1542/peds.103.2.e22. PMID 9925868.
  4. ↑ Baig, M. A.; Lin, Y. S.; Rasheed, J; Mittman, N (2006). "Renal medullary carcinoma". Journal of the National Medical Association 98 (7): 1171–4. PMC 2569460. PMID 16895289.
  5. 1 2 Avery, Robert A.; Harris, Jules E.; Davis, Charles J.; Borgaonkar, Digamber S.; Byrd, John C.; Weiss, Raymond B. (1996). "Renal medullary carcinoma: Clinical and therapeutic aspects of a newly described tumor". Cancer 78 (1): 128–32. doi:10.1002/(SICI)1097-0142(19960701)78:1<128::AID-CNCR18>3.0.CO;2-1. PMID 8646708.
  6. 1 2 Heuermann, K. G.; Romero, J. R.; Abromowitch, M. A.; Gordon, B. G.; Gross, T. G. (1999). "Fatal Coagulase-Negative Staphylococci Infection After Bone Marrow Transplantation in a Patient with Persistent Adverse Reactions to Vancomycin". Journal of Pediatric Hematology/Oncology 21 (1): 80–1. doi:10.1097/00043426-199901000-00019. PMID 10029821.
  7. ↑ Rathmell, W. Kimryn; Monk, J. Paul (2008). "High-Dose-Intensity MVAC for Advanced Renal Medullary Carcinoma: Report of Three Cases and Literature Review". Urology 72 (3): 659–63. doi:10.1016/j.urology.2008.05.009. PMID 18649931.
  8. ↑ Walsh, Alexandra; Kelly, David R.; Vaid, Yoginder N.; Hilliard, Lee M.; Friedman, Gregory K. (2010). "Complete response to carboplatin, gemcitabine, and paclitaxel in a patient with advanced metastatic renal medullary carcinoma". Pediatric Blood & Cancer 55 (6): 1217–20. doi:10.1002/pbc.22611. PMID 20979179.
  9. ↑ Walsh, Alexandra M.; Fiveash, John B.; Reddy, Alyssa T.; Friedman, Gregory K.; Sinclair, E; Yip, D; Ko, Y. J. (2011). "Response to Radiation in Renal Medullary Carcinoma: A Case Report and Review of the Literature". Rare Tumors 3 (3): 1156–61. doi:10.4081/rt.2011.e32. PMID 18980461.
  10. ↑ Watanabe, Isabela C; Billis, Athanase; Guimarães, Marbele S; Alvarenga, Marcelo; De Matos, Amilcar C; Cardinalli, Izilda A; Filippi, Renee Z; De Castro, Marilia G; Suzigan, Sueli (2007). "Renal medullary carcinoma: Report of seven cases from Brazil". Modern Pathology 20 (9): 914–20. doi:10.1038/modpathol.3800934. PMID 17643096.
  11. ↑ Tsaras, Geoffrey; Owusu-Ansah, Amma; Boateng, Freda Owusua; Amoateng-Adjepong, Yaw (2009). "Complications Associated with Sickle Cell Trait: A Brief Narrative Review". The American Journal of Medicine 122 (6): 507. doi:10.1016/j.amjmed.2008.12.020. PMID 19393983.
  12. ↑ Broecker, Bruce (2000). "Non–Wilms' Renal Tumors in Children". Urologic Clinics of North America 27 (3): 463–9, ix. doi:10.1016/S0094-0143(05)70094-X. PMID 10985146.
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