Reptin

Reptin is a tumor repressor protein that is a member of the ATPases Associated with various cellular Activities (AAA+) family and regulates KAI1.^[1] Desumoylation of reptin alters the repressive function of reptin and its association with HDAC1. The sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential. Reptin is reported in 2010 to be a good marker for metastasis.

References

↑ Matias, PM; Baek, SH; Bandeiras, TM; Dutta, A; Houry, WA; Llorca, O; Rosenbaum, J (2015). "The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors.". Frontiers in molecular biosciences 2: 17. doi:10.3389/fmolb.2015.00017. PMID 25988184.

Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis Nature Cell Biology 8, 631 - 639 (2006). Published online: 14 May 2006 | doi:10.1038/ncb1415

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