Ripasudil

Ripasudil
Systematic (IUPAC) name

4-Fluoro-5-{[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl}isoquinoline
Clinical data
Trade names	Glanatec
Identifiers
PubChem	CID 9863672
ChemSpider	8039366
Synonyms	K-115
Chemical data
Formula	C₁₅H₁₈FN₃O₂S
Molar mass	323.39 g/mol
SMILES O=S(=O)(c2c1c(F)cncc1ccc2)N3[C@H](CNCCC3)C
InChI InChI=1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1 Key:QSKQVZWVLOIIEV-NSHDSACASA-N

Ripasudil (Glanatec) is a drug used for the treatment of glaucoma and ocular hypertension. It is approved for use in Japan as a 0.4% ophthalmic solution.^[1]

Ripasudil, a derivative of fasudil, is a rho kinase inhibitor.^[2]

References

↑ Garnock-Jones, K. P. (2014). "Ripasudil: First global approval". Drugs 74 (18): 2211–5. doi:10.1007/s40265-014-0333-2. PMID 25414122.
↑ Tanihara, H; Inoue, T; Yamamoto, T; Kuwayama, Y; Abe, H; Suganami, H; Araie, M; the K-115 Clinical Study Group (2014). "Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: A randomized, open-label, crossover study". Acta Ophthalmologica: n/a. doi:10.1111/aos.12599. PMID 25487877.

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