Robert C. Green

Robert C. Green
Born (1954-10-21) October 21, 1954
Richmond, Virginia
Institutions Brigham and Women's Hospital
Harvard Medical School
Alma mater Amherst College
University of Virginia School of Medicine
Emory University

Robert C. Green (born October 21, 1954) is an American medical geneticist, physician, and public health researcher. He directs the Genomes2People Research Program in translational genomics and health outcomes in the Division of Genetics at Brigham and Women’s Hospital, the Broad Institute and Harvard Medical School.[1] At Harvard Medical School, he teaches medical students and mentors post-doctoral trainees and junior faculty in the clinical and research aspects of genomic medicine. Research led by Green includes the first experimental trials disclosing common complex disease risk (the REVEAL Study); the development of risk estimates for Alzheimer’s disease based on family history and genetic markers;[2][3] and one of the first prospective studies of direct-to-consumer genetic testing services (the PGen Study).[4] He currently leads and co-leads the first randomized trials to explore the implementation of medical sequencing in adults (the MedSeq Project) and newborns (the BabySeq Project), respectively.[5][6][7][8]

He has written extensively on the subject of integrating genomic information into medical practice, and is a frequent speaker on the subject at academic conferences and in mainstream media.[9][10]

Early years and education

Green was born in Richmond, Virginia, and earned an undergraduate degree from Amherst College.[11] He graduated from the University of Virginia School of Medicine,[12] and earned a Masters of Public Health in Epidemiology from Emory University School of Public Health. He completed a residency in neurology at Harvard Medical School’s Longwood Neurology Program, and research fellowships at Beth Israel Deaconess Medical Center (then Beth Israel Hospital) and Boston Children’s Hospital. Green is board-certified in neurology and medical genetics. He taught at the Emory University School of Medicine (1988-1996) and the Boston University School of Medicine (1999-2011) before joining the faculty of Harvard Medical School.[13]

Genomic Research Projects and Contributions

Over his career, Green has published more than 300 papers, with an h-index of 64. His projects have drawn funding from the National Institutes of Health continuously for more than 26 years.[14]

Since 1999, Green has served as Principal Investigator of the Risk Evaluation and Education for Alzheimer’s Disease (REVEAL) Study,[15] which explores the behavioral, and health-related impact of disclosing genetic risk for Alzheimer’s disease. The National Human Genome Research Institute (NHGRI) has funded four cycles of this study, a series of multi-site, randomized, controlled clinical trials that provide empirical data to address ethical, social and translational issues in genetic susceptibility testing for common diseases.[16][17]

Green also co-led (with J. Scott Roberts, Ph.D.) the Impact of Personal Genomics (PGen) Study, one of the first to investigate the characteristics of consumers; the behavioral and health impact; and the translational and social issues associated with personal genomic testing services.[18] He was the lead author on the American College of Medical Genetics and Genomics (ACMG)’s recommendations for reporting incidental findings in clinical exome and genome sequencing.[19] Green also contributed to the design of a variant classification pipeline,[20] and a single page summary for reporting clinically relevant results of whole genome sequencing to physicians.[21]

Green now serves as Director of The MedSeq Project and The BabySeq Project, two joint initiatives of Brigham & Women’s Hospital, Harvard Medical School and Partners Healthcare that examine how whole genome sequencing is integrated into clinical medicine for adult patients (MedSeq) and children (BabySeq).[22][23]

Professional Affiliations and Awards

Green is Associate Director for Research of Partners HealthCare Personalized Medicine and a Board Member of the Council for Responsible Genetics.[24] He co-chairs the Steering Committee of the NIH Consortium on Clinical Sequencing Exploratory Research (CSER) and the Steering Committee of the NIH Consortium in Newborn Sequencing in Genomic Medicine and Public Health (NSIGHT).[25] Green is a funded member of the Consortium on Electronic Medical Records and Genomics (eMERGE).[26] He serves on the Institute of Medicine Committee on the "Evidence Base for Genetic Testing," and has collaborated on research studies with Illumina, 23andMe, Pathway and Google.[27][28][29]

Green’s research and role as genetic counselor has been featured on PBS radio and television documentaries, NBC Nightly News, the Today Show, as well as in the New York Times, the Wall Street Journal, Time Magazine, New Scientist, FastCompany, GenomeWeb and Buzzfeed.[30][31]

Green received the 2014 Coriell Award for Scientific Achievement in Personalized Medicine.[32]

References

  1. ↑ http://www.wsj.com/articles/how-one-family-faced-difficult-decisions-about-dna-sequencing-1443406974
  2. ↑ http://commonhealth.wbur.org/2015/01/genetic-counseling-alzheimers-test
  3. ↑ http://www.nature.com/mp/journal/v21/n1/full/mp201523a.html
  4. ↑ http://www.genengnews.com/insight-and-intelligence/direct-to-consumer-testing-s-constitutional-appeal/77900031/
  5. ↑ http://www.nih.gov/news-events/news-releases/new-report-offers-primer-doctors-use-clinical-genome-exome-sequencing
  6. ↑ http://commonhealth.wbur.org/2013/09/genome-babies-research
  7. ↑ http://news.yahoo.com/gene-scans-solve-mystery-diseases-kids-adults-211439108.html
  8. ↑ http://www.dailymail.co.uk/sciencetech/article-2891662/US-parents-set-offered-experimental-genome-testing-study-finds-robust-technology.html
  9. ↑ http://www.bio-itworld.com/2015/5/6/what-we-are-looking-forward-to-at-bit15.html
  10. ↑ https://exponential.singularityu.org/medicine/november-2015-faculty/robert-c-green/
  11. ↑ https://www.amherst.edu/academiclife/departments/neuroscience/alumni_in_neuroscience
  12. ↑ https://news.virginia.edu/content/todays-highlights-153
  13. ↑ http://www.bu.edu/news/2000/08/16/alzheimer-investigator-joins-boston-university-school-of-medicine/
  14. ↑ http://www.worldsciencefestival.com/participants/robert_c_green/
  15. ↑ http://www.bu.edu/alzresearch/files/pdf/Green_NEJMREVEALIpaper_final6.pdf
  16. ↑ https://www.youtube.com/watch?v=h1_2vF_gJwo
  17. ↑ http://www.genome.gov/Pages/About/NACHGR/Sept2005NACHGRAgenda/ItemsofInterest.pdf
  18. ↑ http://www.genengnews.com/insight-and-intelligence/direct-to-consumer-testing-s-constitutional-appeal/77900031/
  19. ↑ http://www.nature.com/gim/journal/v15/n7/abs/gim201373a.html
  20. ↑ http://onlinelibrary.wiley.com/doi/10.1002/humu.22520/abstract
  21. ↑ https://www.karger.com/Article/Pdf/370102
  22. ↑ http://www.wsj.com/articles/SB10000872396390443884104577645783975993656
  23. ↑ http://commonhealth.wbur.org/2013/09/genome-babies-research
  24. ↑ http://www.councilforresponsiblegenetics.org/blog/post/CRG-Board-Member-Dr-Robert-Green-Discusses-Returning-Genomic-Research-Results-to-Participants.aspx
  25. ↑ http://www.nih.gov/news-events/news-releases/new-report-offers-primer-doctors-use-clinical-genome-exome-sequencing
  26. ↑ http://www.genome.gov/27546194
  27. ↑ http://genomemag.com/uyg/
  28. ↑ http://qz.com/167178/new-evidence-shows-the-fda-was-wrong-to-halt-23andme-testing/
  29. ↑ http://www.genomemedicine.com/content/6/12/96
  30. ↑ http://www.nytimes.com/2014/04/08/science/fearing-punishment-for-bad-genes.html?_r=0
  31. ↑ http://wellesley.wickedlocal.com/article/20071227/NEWS/312279784
  32. ↑ http://www.brighamandwomens.org/About_BWH/publicaffairs/news/awards/Award_Honor.aspx?sub=0&PageID=1760
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