S100A14
S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.[1]
Function
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.[2][3]
References
- ↑ "Entrez Gene: S100 calcium binding protein A14".
- ↑ Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports 23 (1): 45–52. PMID 19956863.
- ↑ Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.
Further reading
- Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
- Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (Jul 2008). "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". Journal of Immunology 181 (2): 1499–1506. doi:10.4049/jimmunol.181.2.1499. PMC 2435511. PMID 18606705.
- Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S (Aug 2009). "Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients". International Journal of Immunogenetics 36 (4): 217–22. doi:10.1111/j.1744-313X.2009.00858.x. PMID 19601998.
- Jin Q, Chen H, Luo A, Ding F, Liu Z (2011). "S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)". PLOS ONE 6 (4): e19375. doi:10.1371/journal.pone.0019375. PMID 21559403.
- Büchau AS, Hassan M, Kukova G, Lewerenz V, Kellermann S, Würthner JU, Wolf R, Walz M, Gallo RL, Ruzicka T (Nov 2007). "S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4". The Journal of Investigative Dermatology 127 (11): 2596–604. doi:10.1038/sj.jid.5700946. PMID 17625598.
- Sapkota D, Costea DE, Blø M, Bruland O, Lorens JB, Vasstrand EN, Ibrahim SO (Mar 2012). "S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest". Oral Oncology 48 (3): 219–25. doi:10.1016/j.oraloncology.2011.10.001. PMID 22032898.
- Boeshans KM, Wolf R, Voscopoulos C, Gillette W, Esposito D, Mueser TC, Yuspa SH, Ahvazi B (May 2006). "Purification, crystallization and preliminary X-ray diffraction of human S100A15". Acta Crystallographica. Section F, Structural Biology and Crystallization Communications 62 (Pt 5): 467–470. doi:10.1107/S1744309106012838. PMC 2219979. PMID 16682778.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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