SAA2
| Serum amyloid A2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbol | SAA2 | ||||||||||||
| External IDs | OMIM: 104751 MGI: 98223 HomoloGene: 133299 GeneCards: SAA2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6289 | 20210 | |||||||||||
| Ensembl | ENSG00000134339 | ENSMUSG00000040026 | |||||||||||
| UniProt | P0DJI9 | P04918 | |||||||||||
| RefSeq (mRNA) | NM_001127380 | NM_011315.3 | |||||||||||
| RefSeq (protein) | NP_001120852 | NP_035445.1 | |||||||||||
| Location (UCSC) |
Chr 11: 18.24 – 18.25 Mb |
Chr 7: 46.71 – 46.72 Mb | |||||||||||
| PubMed search | |||||||||||||
Serum amyloid A protein is a protein that in humans is encoded by the SAA2 gene.[1][2]
References
- ↑ Steel DM, Sellar GC, Uhlar CM, Simon S, DeBeer FC, Whitehead AS (Jul 1993). "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)". Genomics 16 (2): 447–54. doi:10.1006/geno.1993.1209. PMID 7686132.
- ↑ "Entrez Gene: SAA2 Serum amyloid A2".
Further reading
- Betts JC, Edbrooke MR, Thakker RV, Woo P (1991). "The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells.". Scand. J. Immunol. 34 (4): 471–82. doi:10.1111/j.1365-3083.1991.tb01570.x. PMID 1656519.
- Zimlichman S, Danon A, Nathan I, et al. (1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation". J. Lab. Clin. Med. 116 (2): 180–6. PMID 1697614.
- Steinkasserer A, Weiss EH, Schwaeble W, Linke RP (1990). "Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis". Biochem. J. 268 (1): 187–93. PMC 1131410. PMID 1971508.
- Woo P, Sipe J, Dinarello CA, Colten HR (1987). "Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells". J. Biol. Chem. 262 (32): 15790–5. PMID 2890635.
- Kluve-Beckerman B, Dwulet FE, Benson MD (1988). "Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person". J. Clin. Invest. 82 (5): 1670–5. doi:10.1172/JCI113779. PMC 442736. PMID 3183061.
- Kluve-Beckerman B, Long GL, Benson MD (1987). "DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA)". Biochem. Genet. 24 (11–12): 795–803. doi:10.1007/BF00554519. PMID 3800865.
- Meek RL, Hoffman JS, Benditt EP (1986). "Amyloidogenesis. One serum amyloid A isotype is selectively removed from the circulation". J. Exp. Med. 163 (3): 499–510. doi:10.1084/jem.163.3.499. PMC 2188051. PMID 3950541.
- Badolato R, Wang JM, Murphy WJ, et al. (1994). "Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes". J. Exp. Med. 180 (1): 203–9. doi:10.1084/jem.180.1.203. PMC 2191543. PMID 7516407.
- Badolato R, Johnston JA, Wang JM, et al. (1995). "Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway". J. Immunol. 155 (8): 4004–10. PMID 7561109.
- Xu L, Badolato R, Murphy WJ, et al. (1995). "A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion". J. Immunol. 155 (3): 1184–90. PMID 7636186.
- Liepnieks JJ, Kluve-Beckerman B, Benson MD (1995). "Characterization of amyloid A protein in human secondary amyloidosis: the predominant deposition of serum amyloid A1". Biochim. Biophys. Acta 1270 (1): 81–6. doi:10.1016/0925-4439(94)00076-3. PMID 7827140.
- Arai K, Miura K, Baba S, Shirasawa H (1994). "Transformation from SAA2-fibrils to AA-fibrils in amyloid fibrillogenesis: in vivo observations in murine spleen using anti-SAA and anti-AA antibodies". J. Pathol. 173 (2): 127–34. doi:10.1002/path.1711730209. PMID 8089807.
- Meek RL, Urieli-Shoval S, Benditt EP (1994). "Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3186–90. doi:10.1073/pnas.91.8.3186. PMC 43540. PMID 8159722.
- Sellar GC, Jordan SA, Bickmore WA, et al. (1994). "The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis". Genomics 19 (2): 221–7. doi:10.1006/geno.1994.1051. PMID 8188252.
- Ducret A, Bruun CF, Bures EJ, et al. (1996). "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry". Electrophoresis 17 (5): 866–76. doi:10.1002/elps.1150170508. PMID 8783012.
- Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A". J. Biol. Chem. 272 (1): 406–13. doi:10.1074/jbc.272.1.406. PMID 8995276.
- Hershkoviz R, Preciado-Patt L, Lider O, et al. (1997). "Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion". Am. J. Physiol. 273 (1 Pt 1): C179–87. PMID 9252455.
- Migita K, Kawabe Y, Tominaga M, et al. (1998). "Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts". Lab. Invest. 78 (5): 535–9. PMID 9605178.
- Urieli-Shoval S, Cohen P, Eisenberg S, Matzner Y (1999). "Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium". J. Histochem. Cytochem. 46 (12): 1377–84. doi:10.1177/002215549804601206. PMID 9815279.
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