SAT2
This article is about the human gene. For the submarine communications cable, see SAT-2. For the SAT II tests, see SAT Subject Tests.
| Spermidine/spermine N1-acetyltransferase family member 2 | |||||||||||||
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PDB rendering based on 2bei. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SAT2 ; SSAT2 | ||||||||||||
| External IDs | OMIM: 611463 MGI: 1916465 HomoloGene: 44215 GeneCards: SAT2 Gene | ||||||||||||
| EC number | 2.3.1.57 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 112483 | 69215 | |||||||||||
| Ensembl | ENSG00000141504 | ENSMUSG00000069835 | |||||||||||
| UniProt | Q96F10 | Q6P8J2 | |||||||||||
| RefSeq (mRNA) | NM_133491 | NM_026991 | |||||||||||
| RefSeq (protein) | NP_597998 | NP_081267 | |||||||||||
| Location (UCSC) |
Chr 17: 7.63 – 7.63 Mb |
Chr 11: 69.62 – 69.62 Mb | |||||||||||
| PubMed search | |||||||||||||
Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[1][2][3] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[4]
References
- ↑ Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.
- ↑ Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.
- ↑ "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
- ↑ Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA. (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.". Cereb Cortex 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.
Further reading
- Baek JH, Liu YV, McDonald KR, et al. (2008). "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.". J. Biol. Chem. 282 (46): 33358–66. doi:10.1074/jbc.M705627200. PMID 17875644.
- Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.". Mol. Cell. Biochem. 298 (1–2): 59–68. doi:10.1007/s11010-006-9350-0. PMID 17119850.
- Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006). "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins 64 (1): 288–93. doi:10.1002/prot.20967. PMID 16596569.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chen Y, Vujcic S, Liang P, et al. (2003). "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase". Biochem. J. 373 (Pt 3): 661–7. doi:10.1042/BJ20030734. PMC 1223561. PMID 12803540.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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