SAV1

Salvador family WW domain containing protein 1
PDB rendering based on 2dwv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2dwv​
Identifiers
Symbols	SAV1 ; SAV; WW45; WWP4
External IDs	OMIM: 607203 MGI: 1927144 HomoloGene: 32517 GeneCards: SAV1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytoplasm • cytosol Biological process • hair follicle development • keratinocyte differentiation • hippo signaling • positive regulation of apoptotic process • positive regulation of fat cell differentiation • negative regulation of epithelial cell proliferation • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of cardiac muscle cell proliferation • ventricular septum morphogenesis • lung epithelial cell differentiation • intestinal epithelial cell differentiation • regulation of stem cell maintenance Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60485	64010
Ensembl	ENSG00000151748	ENSMUSG00000021067
UniProt	Q9H4B6	Q8VEB2
RefSeq (mRNA)	NM_021818	NM_022028
RefSeq (protein)	NP_068590	NP_071311
Location (UCSC)	Chr 14: 50.63 – 50.67 Mb	Chr 12: 69.97 – 69.99 Mb
PubMed search

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.^[1][2][3]

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.^[3]

References

1. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell 110 (4): 467–78. doi:10.1016/S0092-8674(02)00824-3. PMID 12202036.
2. Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580.
3. "Entrez Gene: SAV1 salvador homolog 1 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yoo NJ, Soung YH, Lee JW, et al. (2003). "Mutational analysis of salvador gene in human carcinomas". APMIS 111 (6): 595–8. doi:10.1034/j.1600-0463.2003.1110601.x. PMID 12969014.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Callus BA, Verhagen AM, Vaux DL (2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation". FEBS J. 273 (18): 4264–76. doi:10.1111/j.1742-4658.2006.05427.x. PMID 16930133.