SB 203580

SB 203580[1]
Names
IUPAC name
4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
Other names
RWJ-64809;
Identifiers
152121-47-6 YesY
ChEMBL ChEMBL10 N
ChemSpider 153453 N
5269
Jmol interactive 3D Image
PubChem 176155
Properties
C21H16FN3OS
Molar mass 377.43 g/mol
Appearance White to off-white solid
Solubility in DMSO 50 mg/mL
Hazards
Main hazards Xn
R-phrases R22 R41
S-phrases S26 S39
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.

References


This article is issued from Wikipedia - version of the Monday, November 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.