SCARB1

Scavenger receptor class B, member 1
Identifiers
Symbols	SCARB1 ; CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1
External IDs	OMIM: 601040 MGI: 893578 HomoloGene: 21132 GeneCards: SCARB1 Gene
Gene ontology Molecular function • lipopolysaccharide binding • phosphatidylserine binding • lipopolysaccharide receptor activity • transporter activity • protein binding • 1-phosphatidylinositol binding • high-density lipoprotein particle binding • low-density lipoprotein particle binding • apolipoprotein binding • apolipoprotein A-I binding • protein homodimerization activity • high-density lipoprotein particle receptor activity Cellular component • lysosomal membrane • plasma membrane • integral component of plasma membrane • caveola • cell surface • endocytic vesicle membrane • microvillus membrane • extracellular exosome Biological process • endothelial cell proliferation • androgen biosynthetic process • cholesterol catabolic process • receptor-mediated endocytosis • cell adhesion • positive regulation of endothelial cell migration • positive regulation of triglyceride biosynthetic process • positive regulation of cholesterol storage • regulation of phosphatidylcholine catabolic process • phospholipid transport • lipopolysaccharide transport • viral process • lipopolysaccharide-mediated signaling pathway • detection of lipopolysaccharide • cholesterol efflux • high-density lipoprotein particle remodeling • low-density lipoprotein particle clearance • high-density lipoprotein particle clearance • vitamin transmembrane transport • wound healing • lipoprotein metabolic process • cholesterol homeostasis • blood vessel endothelial cell migration • recognition of apoptotic cell • reverse cholesterol transport • small molecule metabolic process • adhesion of symbiont to host • regulation of phagocytosis • positive regulation of nitric-oxide synthase activity • triglyceride homeostasis • cholesterol import Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	949	20778
Ensembl	ENSG00000073060	ENSMUSG00000037936
UniProt	Q8WTV0	Q61009
RefSeq (mRNA)	NM_001082959	NM_001205082
RefSeq (protein)	NP_001076428	NP_001192011
Location (UCSC)	Chr 12: 124.78 – 124.88 Mb	Chr 5: 125.28 – 125.34 Mb
PubMed search

Scavenger receptor class B member 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene.^[1] SR-BI functions as a receptor for high-density lipoprotein.^[2]

Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver for excretion. This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.

SR-BI has also been identified in the livers of non-mammalian species (turtle, goldfish, shark, chicken, frog, and skate), suggesting it emerged early in vertebrate evolutionary history. The turtle also seems to upregulate SB-RI during egg development, indicating that cholesterol efflux may be at peak levels during developmental stages.^[3]

In melanocytic cells SCARB1 gene expression may be regulated by the MITF.^[4]

SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus in liver cells.^[5]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Statin Pathway edit]]

Statin Pathway edit

1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

1. "Entrez Gene: SCARB1 Scavenger receptor class B, member 1".
2. Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH, Krieger M (January 1996). "Identification of scavenger receptor SR-BI as a high density lipoprotein receptor". Science 271 (5248): 518–20. doi:10.1126/science.271.5248.518. PMID 8560269.
3. Duggan AE, Marie RS, Callard IP (April 2002). "Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates". J. Exp. Zool. 292 (5): 430–4. doi:10.1002/jez.10067. PMID 11857477.
4. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
5. Kapadia SB, Barth H, Baumert T, McKeating JA, Chisari FV (January 2007). "Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I". J. Virol. 81 (1): 374–83. doi:10.1128/JVI.01134-06. PMC 1797271. PMID 17050612.

Further reading

• Williams DL, Temel RE, Connelly MA (2001). "Roles of scavenger receptor BI and APO A-I in selective uptake of HDL cholesterol by adrenal cells.". Endocr. Res. 26 (4): 639–51. doi:10.3109/07435800009048584. PMID 11196441.
• Krause BR, Auerbach BJ (2001). "Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis.". Current opinion in investigational drugs (London, England : 2000) 2 (3): 375–81. PMID 11575708.
• Connelly MA, Williams DL (2005). "Scavenger receptor BI: a scavenger receptor with a mission to transport high density lipoprotein lipids.". Curr. Opin. Lipidol. 15 (3): 287–95. doi:10.1097/00041433-200406000-00008. PMID 15166784.
• Phillips RW (1978). "The new era in restorative dental materials.". Oper Dent 1 (1): 29–35. PMID 1076467.
• Skre H, Berg K (1974). "Cerebellar ataxia and total albinism: a kindred suggesting pleitotropism or linkage.". Clin. Genet. 5 (3): 196–204. doi:10.1111/j.1399-0004.1974.tb01682.x. PMID 4838888.
• Calvo D, Dopazo J, Vega MA (1995). "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution.". Genomics 25 (1): 100–6. doi:10.1016/0888-7543(95)80114-2. PMID 7539776.
• Calvo D, Vega MA (1993). "Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family.". J. Biol. Chem. 268 (25): 18929–35. PMID 7689561.
• Murao K, Terpstra V, Green SR, et al. (1997). "Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes.". J. Biol. Chem. 272 (28): 17551–7. doi:10.1074/jbc.272.28.17551. PMID 9211901.
• Ikemoto M, Arai H, Feng D, et al. (2000). "Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.". Proc. Natl. Acad. Sci. U.S.A. 97 (12): 6538–43. doi:10.1073/pnas.100114397. PMC 18651. PMID 10829064.
• Husemann J, Silverstein SC (2001). "Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain.". Am. J. Pathol. 158 (3): 825–32. doi:10.1016/S0002-9440(10)64030-8. PMC 1850374. PMID 11238031.
• Li XA, Titlow WB, Jackson BA, et al. (2002). "High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner.". J. Biol. Chem. 277 (13): 11058–63. doi:10.1074/jbc.M110985200. PMID 11792700.
• Duncan KG, Bailey KR, Kane JP, Schwartz DM (2002). "Human retinal pigment epithelial cells express scavenger receptors BI and BII.". Biochem. Biophys. Res. Commun. 292 (4): 1017–22. doi:10.1006/bbrc.2002.6756. PMID 11944916.
• Kawasaki Y, Nakagawa A, Nagaosa K, et al. (2002). "Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells.". J. Biol. Chem. 277 (30): 27559–66. doi:10.1074/jbc.M202879200. PMID 12016218.
• Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952.
• Johnson MS, Svensson PA, Borén J, et al. (2002). "Expression of scavenger receptor class B type I in gallbladder columnar epithelium.". J. Gastroenterol. Hepatol. 17 (6): 713–20. doi:10.1046/j.1440-1746.2002.02776.x. PMID 12100619.
• Silver DL (2002). "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver.". J. Biol. Chem. 277 (37): 34042–7. doi:10.1074/jbc.M206584200. PMID 12119305.
• Bultel-Brienne S, Lestavel S, Pilon A, et al. (2002). "Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins.". J. Biol. Chem. 277 (39): 36092–9. doi:10.1074/jbc.M201943200. PMID 12138091.
• Strauss JG, Zimmermann R, Hrzenjak A, et al. (2002). "Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.". Biochem. J. 368 (Pt 1): 69–79. doi:10.1042/BJ20020306. PMC 1222966. PMID 12164779.