SCFD1

Sec1 family domain containing 1
PDB rendering based on 1y9j.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1y9j​
Identifiers
Symbols	SCFD1 ; C14orf163; RA410; SLY1; SLY1P; STXBP1L2
External IDs	MGI: 1924233 HomoloGene: 5650 GeneCards: SCFD1 Gene
Gene ontology Molecular function • protein binding • syntaxin binding • protein N-terminus binding Cellular component • endoplasmic reticulum membrane • Golgi-associated vesicle • cis-Golgi network • plasma membrane • Golgi transport complex • SNARE complex • Golgi cisterna membrane Biological process • cell morphogenesis • response to hypoxia • retrograde vesicle-mediated transport, Golgi to ER • post-Golgi vesicle-mediated transport • vesicle docking involved in exocytosis • phagocytosis • response to toxic substance • protein transport • regulation of protein transport • regulation of ER to Golgi vesicle-mediated transport • toxin transport • negative regulation of autophagosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23256	76983
Ensembl	ENSG00000092108	ENSMUSG00000020952
UniProt	Q8WVM8	Q8BRF7
RefSeq (mRNA)	NM_001257376	NM_001306178
RefSeq (protein)	NP_001244305	NP_001293107
Location (UCSC)	Chr 14: 30.62 – 30.74 Mb	Chr 12: 51.38 – 51.45 Mb
PubMed search

Sec1 family domain-containing protein 1 is a protein that in humans is encoded by the SCFD1 gene.^[1]

Interactions

SCFD1 has been shown to interact with USO1.^[2][3]

References

1. "Entrez Gene: SCFD1 sec1 family domain containing 1".
2. Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
3. Allan BB, Moyer BD, Balch WE (July 2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Williams AL, Ehm S, Jacobson NC, Xu D, Hay JC (2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility". Mol. Biol. Cell 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMC 307537. PMID 14565970.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC (2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 32–7. doi:10.1073/pnas.232701299. PMC 140874. PMID 12506202.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Matsuo N, Ogawa S, Takagi T, Wanaka A, Mori T, Matsuyama T, Pinsky DJ, Stern DM, Tohyama M (1997). "Cloning of a putative vesicle transport-related protein, RA410, from cultured rat astrocytes and its expression in ischemic rat brain". J. Biol. Chem. 272 (26): 16438–44. doi:10.1074/jbc.272.26.16438. PMID 9195952.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.