SCGB3A1
| Secretoglobin, family 3A, member 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SCGB3A1 ; HIN-1; HIN1; LU105; PnSP-2; UGRP2 | ||||||||||||
| External IDs | OMIM: 606500 MGI: 1915912 HomoloGene: 14160 GeneCards: SCGB3A1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 92304 | 68662 | |||||||||||
| Ensembl | ENSG00000161055 | ENSMUSG00000064057 | |||||||||||
| UniProt | Q96QR1 | Q920D7 | |||||||||||
| RefSeq (mRNA) | NM_052863 | NM_054037 | |||||||||||
| RefSeq (protein) | NP_443095 | NP_473378 | |||||||||||
| Location (UCSC) |
Chr 5: 180.59 – 180.59 Mb |
Chr 11: 49.66 – 49.67 Mb | |||||||||||
| PubMed search | |||||||||||||
Secretoglobin family 3A member 1 is a protein that in humans is encoded by the SCGB3A1 gene.[1][2][3]
References
- ↑ Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S (Oct 2001). "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor". Mol Endocrinol 15 (11): 2021–36. doi:10.1210/me.15.11.2021. PMID 11682631.
- ↑ Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K (Aug 2001). "HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells". Proc Natl Acad Sci U S A 98 (17): 9796–801. doi:10.1073/pnas.171138398. PMC 55532. PMID 11481438.
- ↑ "Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1".
Further reading
- Porter D, Lahti-Domenici J, Torres-Arzayus M, et al. (2003). "Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues.". Mech. Dev. 114 (1-2): 201–4. doi:10.1016/S0925-4773(02)00056-4. PMID 12175512.
- Reynolds SD, Reynolds PR, Pryhuber GS, et al. (2003). "Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways.". Am. J. Respir. Crit. Care Med. 166 (11): 1498–509. doi:10.1164/rccm.200204-285OC. PMID 12406855.
- Niimi T, Copeland NG, Gilbert DJ, et al. (2003). "Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family.". Cytogenet. Genome Res. 97 (1-2): 120–7. doi:10.1159/000064067. PMID 12438750.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Krop I, Maguire P, Lahti-Domenici J, et al. (2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.". Cancer Res. 63 (9): 2024–7. PMID 12727813.
- Bin LH, Nielson LD, Liu X, et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair.". J. Immunol. 171 (2): 924–30. doi:10.4049/jimmunol.171.2.924. PMID 12847263.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Fackler MJ, McVeigh M, Evron E, et al. (2004). "DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma.". Int. J. Cancer 107 (6): 970–5. doi:10.1002/ijc.11508. PMID 14601057.
- Tisserand P, Fouquet C, Barrois M, et al. (2004). "Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors.". Cancer Biol. Ther. 2 (5): 559–63. doi:10.4161/cbt.2.5.511. PMID 14614327.
- Marchetti A, Barassi F, Martella C, et al. (2004). "Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome.". Clin. Cancer Res. 10 (4): 1338–43. doi:10.1158/1078-0432.CCR-1174-03. PMID 14977834.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Krop I, Player A, Tablante A, et al. (2005). "Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types.". Mol. Cancer Res. 2 (9): 489–94. PMID 15383627.
- Shigematsu H, Suzuki M, Takahashi T, et al. (2005). "Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies.". Int. J. Cancer 113 (4): 600–4. doi:10.1002/ijc.20622. PMID 15472908.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Krop I, Parker MT, Bloushtain-Qimron N, et al. (2005). "HIN-1, an inhibitor of cell growth, invasion, and AKT activation.". Cancer Res. 65 (21): 9659–69. doi:10.1158/0008-5472.CAN-05-1663. PMID 16266985.
- Yang Q, Kiernan CM, Tian Y, et al. (2007). "Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome.". Clin. Cancer Res. 13 (11): 3191–7. doi:10.1158/1078-0432.CCR-06-2846. PMID 17545522.
- Wu Q, Lothe RA, Ahlquist T, et al. (2007). "DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.". Mol. Cancer 6: 45. doi:10.1186/1476-4598-6-45. PMC 1964763. PMID 17623056.
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