Secretagogin
| Secretagogin, EF-hand calcium binding protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SCGN ; CALBL; DJ501N12.8; SECRET; SEGN; setagin | ||||||||||||
| External IDs | OMIM: 609202 MGI: 2384873 HomoloGene: 5088 GeneCards: SCGN Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10590 | 214189 | |||||||||||
| Ensembl | ENSG00000079689 | ENSMUSG00000021337 | |||||||||||
| UniProt | O76038 | Q91WD9 | |||||||||||
| RefSeq (mRNA) | NM_006998 | NM_145399 | |||||||||||
| RefSeq (protein) | NP_008929 | NP_663374 | |||||||||||
| Location (UCSC) |
Chr 6: 25.65 – 25.7 Mb |
Chr 13: 23.95 – 23.99 Mb | |||||||||||
| PubMed search | |||||||||||||
Secretagogin is a protein that in humans is encoded by the SCGN gene.[1][2]
Function
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[2] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.
References
- ↑ Wagner L, Oliyarnyk O, Gartner W, Nowotny P, Groeger M, Kaserer K, Waldhausl W, Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
- 1 2 "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".
Further reading
- Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Zhan X, Evans CO, Oyesiku NM, Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
- Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
- Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
- Romanov R., Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release.". EMBO Journal 34: 36–54. doi:10.15252/embj.201488977.
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