Secretagogin

Secretagogin, EF-hand calcium binding protein
Identifiers
Symbols	SCGN ; CALBL; DJ501N12.8; SECRET; SEGN; setagin
External IDs	OMIM: 609202 MGI: 2384873 HomoloGene: 5088 GeneCards: SCGN Gene
Gene ontology Molecular function • calcium ion binding Cellular component • extracellular region • nucleus • cytoplasm • cytosol • transport vesicle membrane • neuron projection • synapse Biological process • biological_process • cytosolic calcium ion homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10590	214189
Ensembl	ENSG00000079689	ENSMUSG00000021337
UniProt	O76038	Q91WD9
RefSeq (mRNA)	NM_006998	NM_145399
RefSeq (protein)	NP_008929	NP_663374
Location (UCSC)	Chr 6: 25.65 – 25.7 Mb	Chr 13: 23.95 – 23.99 Mb
PubMed search

Secretagogin is a protein that in humans is encoded by the SCGN gene.^[1][2]

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.^[2] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

1. Wagner L, Oliyarnyk O, Gartner W, Nowotny P, Groeger M, Kaserer K, Waldhausl W, Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem 275 (32): 24740–51. doi:10.1074/jbc.M001974200. PMID 10811645.
2. "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

• Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex 11 (12): 1161–9. doi:10.1093/cercor/11.12.1161. PMID 11709487.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Zhan X, Evans CO, Oyesiku NM, Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary 6 (4): 189–202. doi:10.1023/B:PITU.0000023426.99808.40. PMID 15237930.
• Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. doi:10.1016/j.bbrc.2005.02.093. PMID 15766553.
• Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639–45. doi:10.1111/j.1365-3083.2006.01854.x. PMID 17083620.
• Romanov R., Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release.". EMBO Journal 34: 36–54. doi:10.15252/embj.201488977.