SCMH1

Sex comb on midleg homolog 1 (Drosophila)
PDB rendering based on 2p0k.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2P0K​
Identifiers
Symbols	SCMH1 ; Scml3
External IDs	OMIM: 616396 MGI: 1352762 HomoloGene: 32146 GeneCards: SCMH1 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • nucleus • nucleoplasm • chromocenter Biological process • chromatin remodeling • transcription, DNA-templated • spermatogenesis • anatomical structure morphogenesis • anterior/posterior pattern specification • gene silencing • protein sumoylation • post-translational protein modification • cellular protein metabolic process • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22955	29871
Ensembl	ENSG00000010803	ENSMUSG00000000085
UniProt	Q96GD3	Q8K214
RefSeq (mRNA)	NM_001031694	NM_001159630
RefSeq (protein)	NP_001026864	NP_001153102
Location (UCSC)	Chr 1: 41.03 – 41.24 Mb	Chr 4: 120.41 – 120.53 Mb
PubMed search

Polycomb protein SCMH1 is a protein that in humans is encoded by the SCMH1 gene.^[1][2]

References

1. Berger J, Kurahashi H, Takihara Y, Shimada K, Brock HW, Randazzo F (Nov 1999). "The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34". Gene 237 (1): 185–191. doi:10.1016/S0378-1119(99)00285-1. PMID 10524249.
2. "Entrez Gene: SCMH1 sex comb on midleg homolog 1 (Drosophila)".

Further reading

• Tomotsune D, Takihara Y, Berger J, et al. (2000). "A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro". Differentiation 65 (4): 229–239. doi:10.1046/j.1432-0436.1999.6540229.x. PMID 10653359.
• Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Luo L, Yang X, Takihara Y, et al. (2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions". Nature 427 (6976): 749–753. doi:10.1038/nature02305. PMID 14973489.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.