SCYL2

SCY1-like, kinase-like 2
Identifiers
Symbols	SCYL2 ; CVAK104
External IDs	OMIM: 616365 MGI: 1289172 HomoloGene: 13349 GeneCards: SCYL2 Gene
Gene ontology Molecular function • protein kinase activity • receptor binding • protein binding • ATP binding Cellular component • Golgi apparatus • endosome membrane • clathrin-coated vesicle • perinuclear region of cytoplasm Biological process • positive regulation of receptor internalization • protein phosphorylation • endosome to lysosome transport • negative regulation of canonical Wnt signaling pathway • receptor internalization involved in canonical Wnt signaling pathway • positive regulation of clathrin-mediated endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55681	213326
Ensembl	ENSG00000136021	ENSMUSG00000069539
UniProt	Q6P3W7	Q8CFE4
RefSeq (mRNA)	NM_017988	NM_198021
RefSeq (protein)	NP_060458	NP_932138
Location (UCSC)	Chr 12: 100.27 – 100.34 Mb	Chr 10: 89.64 – 89.69 Mb
PubMed search

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene.^[1][2]

References

1. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
2. "Entrez Gene: SCYL2 SCY1-like 2 (S. cerevisiae)".

Further reading

• Borner GH, Rana AA, Forster R, et al. (2007). "CVAK104 is a Novel Regulator of Clathrin-mediated SNARE Sorting". Traffic 8 (7): 893–903. doi:10.1111/j.1600-0854.2007.00576.x. PMC 2239300. PMID 17587408.
• Düwel M, Ungewickell EJ (2007). "Clathrin-dependent Association of CVAK104 with Endosomes and the Trans-Golgi Network". Mol. Biol. Cell 17 (10): 4513–25. doi:10.1091/mbc.E06-05-0390. PMC 1635376. PMID 16914521.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.
• Conner SD, Schmid SL (2005). "CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2". J. Biol. Chem. 280 (22): 21539–44. doi:10.1074/jbc.M502462200. PMID 15809293.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.