SDC2

Syndecan 2
Identifiers
Symbols	SDC2 ; CD362; HSPG; HSPG1; SYND2
External IDs	OMIM: 142460 MGI: 1349165 HomoloGene: 2253 GeneCards: SDC2 Gene
Gene ontology Molecular function • protein binding • PDZ domain binding Cellular component • Golgi lumen • plasma membrane • cell surface • integral component of membrane • lysosomal lumen Biological process • retinoid metabolic process • carbohydrate metabolic process • glycosaminoglycan biosynthetic process • glycosaminoglycan catabolic process • axon guidance • phototransduction, visible light • biological_process • cell migration • extracellular matrix organization • glycosaminoglycan metabolic process • chondroitin sulfate metabolic process • small molecule metabolic process • ephrin receptor signaling pathway • dendrite morphogenesis • regulation of dendrite morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6383	15529
Ensembl	ENSG00000169439	ENSMUSG00000022261
UniProt	P34741	P43407
RefSeq (mRNA)	NM_002998	NM_008304
RefSeq (protein)	NP_002989	NP_032330
Location (UCSC)	Chr 8: 96.49 – 96.61 Mb	Chr 15: 32.92 – 33.03 Mb
PubMed search

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.^[1]

Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.^[2]

Interactions

SDC2 has been shown to interact with:

• CASK,^[3][4]
• Laminin, alpha 3,^[5] and
• EZR^[6]

References

1. David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development 119 (3): 841–54. PMID 8187643.
2. "Entrez Gene: SDC2 syndecan 2".
3. Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536.
4. Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (July 1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.
5. Utani A, Nomizu M, Matsuura H, Kato K, Kobayashi T, Takeda U, Aota S, Nielsen PK, Shinkai H (August 2001). "A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4". J. Biol. Chem. 276 (31): 28779–88. doi:10.1074/jbc.M101420200. PMID 11373281.
6. Granés F, Urena JM, Rocamora N, Vilaró S (April 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell. Sci. 113 ( Pt 7): 1267–76. PMID 10704377.

Further reading

• Mahley RW, Ji ZS (1999). "Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.". J. Lipid Res. 40 (1): 1–16. PMID 9869645.
• Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts.". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7. PMID 1315572.
• Marynen P, Zhang J, Cassiman JJ, Van den Berghe H, David G (1989). "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts.". J. Biol. Chem. 264 (12): 7017–24. PMID 2523388.
• Sage H, Vernon RB, Funk SE, Everitt EA, Angello J (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.". J. Cell Biol. 109 (1): 341–56. doi:10.1083/jcb.109.1.341. PMC 2115491. PMID 2745554.
• Lories V, De Boeck H, David G, Cassiman JJ, Van den Berghe H (1987). "Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms.". J. Biol. Chem. 262 (2): 854–9. PMID 2948951.
• Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor.". Biochemistry 33 (46): 13918–27. doi:10.1021/bi00250a047. PMID 7524669.
• Bolton P, Powell J, Rutter M, Buckle V, Yates JR, Ishikawa-Brush Y, Monaco AP (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1).". Psychiatr. Genet. 5 (2): 51–5. doi:10.1097/00041444-199522000-00001. PMID 7551962.
• Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. doi:10.1073/pnas.90.17.7941. PMC 47263. PMID 7690138.
• Lyon M, Deakin JA, Mizuno K, Nakamura T, Gallagher JT (1994). "Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants.". J. Biol. Chem. 269 (15): 11216–23. PMID 8157651.
• Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, Paglialunga G, Bussolino F, Noonan D (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor.". Oncogene 12 (2): 289–97. PMID 8570206.
• Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanié L, Petit C (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system.". J. Cell. Sci. 109 (7): 1749–57. PMID 8832397.
• Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells.". Am. J. Physiol. 271 (6 Pt 1): G993–1002. PMID 8997243.
• Rusnati M, Coltrini D, Oreste P, Zoppetti G, Albini A, Noonan D, d'Adda di Fagagna F, Giacca M, Presta M (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size.". J. Biol. Chem. 272 (17): 11313–20. doi:10.1074/jbc.272.17.11313. PMID 9111037.
• Oh ES, Couchman JR, Woods A (1997). "Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain.". Arch. Biochem. Biophys. 344 (1): 67–74. doi:10.1006/abbi.1997.0180. PMID 9244383.
• Ishikawa-Brush Y, Powell JF, Bolton P, Miller AP, Francis F, Willard HF, Lehrach H, Monaco AP (1997). "Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene.". Hum. Mol. Genet. 6 (8): 1241–50. doi:10.1093/hmg/6.8.1241. PMID 9259269.
• Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region.". AIDS 11 (12): 1421–31. doi:10.1097/00002030-199712000-00006. PMID 9342064.
• Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Dürr J, David G (1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13683–8. doi:10.1073/pnas.94.25.13683. PMC 28366. PMID 9391086.
• Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.