SEC13

SEC13 homolog, nuclear pore and COPII coat complex component
Rendering based on PDB 3BG0​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BG0​, 3BG1​
Identifiers
Symbols	SEC13 ; D3S1231E; SEC13L1; SEC13R; npp-20
External IDs	OMIM: 600152 MGI: 99832 HomoloGene: 6479 GeneCards: SEC13 Gene
Gene ontology Molecular function • protein binding Cellular component • Golgi membrane • kinetochore • nuclear envelope • endoplasmic reticulum membrane • cytosol • ER to Golgi transport vesicle membrane • nuclear pore outer ring • GATOR2 complex • extracellular exosome Biological process • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • intracellular protein transport • ER to Golgi vesicle-mediated transport • small GTPase mediated signal transduction • protein N-linked glycosylation via asparagine • antigen processing and presentation of exogenous peptide antigen via MHC class II • positive regulation of TOR signaling • post-translational protein modification • cellular protein metabolic process • COPII vesicle coating • mRNA transport • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6396	110379
Ensembl	ENSG00000157020	ENSMUSG00000030298
UniProt	P55735	Q9D1M0
RefSeq (mRNA)	NM_001136026	NM_024206
RefSeq (protein)	NP_001129498	NP_077168
Location (UCSC)	Chr 3: 10.29 – 10.32 Mb	Chr 6: 113.73 – 113.74 Mb
PubMed search

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.^[1][2]

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It has similarity to the yeast SEC13 and SEC31 proteins, which are required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins.^[2]

References

1. Swaroop A, Yang-Feng TL, Liu W, Gieser L, Barrow LL, Chen KC, Agarwal N, Meisler MH, Smith DI (Jan 1995). "Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6". Hum Mol Genet 3 (8): 1281–6. doi:10.1093/hmg/3.8.1281. PMID 7987303.
2. "Entrez Gene: SEC13 SEC13 homolog (S. cerevisiae)".

Further reading

• Shaywitz DA, Orci L, Ravazzola M, et al. (1995). "Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum.". J. Cell Biol. 128 (5): 769–77. doi:10.1083/jcb.128.5.769. PMC 2120388. PMID 7876304.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mammoto A, Sasaki T, Kim Y, Takai Y (2000). "Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking.". J. Biol. Chem. 275 (18): 13167–70. doi:10.1074/jbc.C000096200. PMID 10747849.
• Tang BL, Zhang T, Low DY, et al. (2000). "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.". J. Biol. Chem. 275 (18): 13597–604. doi:10.1074/jbc.275.18.13597. PMID 10788476.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Enninga J, Levay A, Fontoura BM (2003). "Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex.". Mol. Cell. Biol. 23 (20): 7271–84. doi:10.1128/MCB.23.20.7271-7284.2003. PMC 230331. PMID 14517296.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Stagg SM, Gürkan C, Fowler DM, et al. (2006). "Structure of the Sec13/31 COPII coat cage.". Nature 439 (7073): 234–8. doi:10.1038/nature04339. PMID 16407955.