SEC22B

SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
PDB rendering based on 1ifq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2NUP​, 2NUT​, 3EGD​, 3EGX​
Identifiers
Symbols	SEC22B ; ERS-24; SEC22L1
External IDs	OMIM: 604029 MGI: 1338759 HomoloGene: 3597 GeneCards: SEC22B Gene
Gene ontology Molecular function • protein binding • syntaxin binding Cellular component • Golgi membrane • endoplasmic reticulum membrane • endoplasmic reticulum-Golgi intermediate compartment • integral component of membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • melanosome Biological process • ER to Golgi vesicle-mediated transport • protein transport • regulation of organelle organization • positive regulation of protein catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9554	20333
Ensembl	ENSG00000265808	ENSMUSG00000027879
UniProt	O75396	O08547
RefSeq (mRNA)	NM_004892	NM_011342
RefSeq (protein)	NP_004883	NP_035472
Location (UCSC)	Chr 1: 120.15 – 120.18 Mb	Chr 3: 97.9 – 97.92 Mb
PubMed search

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.^[1][2][3]

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.^[3] SEC22B has been shown to interact with syntaxin 18.

References

1. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
2. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I (Feb 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". J Biol Chem 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
3. "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".

Further reading

• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Xu D, Joglekar AP, Williams AL, Hay JC (2001). "Subunit structure of a mammalian ER/Golgi SNARE complex". J. Biol. Chem. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
• Parlati F, McNew JA, Fukuda R, et al. (2000). "Topological restriction of SNARE-dependent membrane fusion". Nature 407 (6801): 194–8. doi:10.1038/35025076. PMID 11001058.
• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.