SEC23B

Sec23 homolog B, COPII coat complex component
Identifiers
Symbols	SEC23B ; CDA-II; CDAII; CDAN2; HEMPAS
External IDs	OMIM: 610512 MGI: 1350925 HomoloGene: 74571 GeneCards: SEC23B Gene
Gene ontology Molecular function • protein binding • zinc ion binding Cellular component • Golgi membrane • endoplasmic reticulum membrane • endomembrane system • membrane • COPII vesicle coat • endoplasmic reticulum-Golgi intermediate compartment membrane • intracellular membrane-bounded organelle • perinuclear region of cytoplasm Biological process • intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle-mediated transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10483	27054
Ensembl	ENSG00000101310	ENSMUSG00000027429
UniProt	Q15437	Q9D662
RefSeq (mRNA)	NM_001172745	NM_001252543
RefSeq (protein)	NP_001166216	NP_001239472
Location (UCSC)	Chr 20: 18.51 – 18.56 Mb	Chr 2: 144.56 – 144.59 Mb
PubMed search

Protein transport protein Sec23B is a protein that in humans is encoded by the SEC23B gene.^[1][2][3]

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3] Mutations in SEC23B cause an autosomal recessive disorder called congenital dyserythropoietic anemia type II (CDAII).

References

1. Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L (Mar 1997). "Cloning and functional characterization of mammalian homologues of the COPII component Sec23". Mol Biol Cell 7 (10): 1535–46. doi:10.1091/mbc.7.10.1535. PMC 276004. PMID 8898360.
2. Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
3. "Entrez Gene: SEC23B Sec23 homolog B (S. cerevisiae)".

Further reading

• Pagano A, Letourneur F, Garcia-Estefania D, et al. (1999). "Sec24 proteins and sorting at the endoplasmic reticulum.". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.