SEC31A

SEC31 homolog A, COPII coat complex component
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SEC31A ; ABP125; ABP130; HSPC275; HSPC334; SEC31L1
External IDs OMIM: 610257 MGI: 1916412 HomoloGene: 42056 GeneCards: SEC31A Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 22872 69162
Ensembl ENSG00000138674 ENSMUSG00000035325
UniProt O94979 Q3UPL0
RefSeq (mRNA) NM_001077206 NM_026969
RefSeq (protein) NP_001070674 NP_081245
Location (UCSC) Chr 4:
82.82 – 82.9 Mb
Chr 5:
100.36 – 100.42 Mb
PubMed search

Protein transport protein Sec31A is a protein that in humans is encoded by the SEC31A gene.[1][2][3]

The protein encoded by this gene is similar to yeast Sec31 protein. Yeast SEC31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

References

  1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  2. Tang BL, Zhang T, Low DY, Wong ET, Horstmann H, Hong W (Jun 2000). "Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport". J Biol Chem 275 (18): 13597–604. doi:10.1074/jbc.275.18.13597. PMID 10788476.
  3. 1 2 "Entrez Gene: SEC31A SEC31 homolog A (S. cerevisiae)".

Further reading

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