SEC61B

Sec61 translocon beta subunit
Identifiers
Symbol	SEC61B
External IDs	OMIM: 609214 MGI: 1913462 HomoloGene: 38229 GeneCards: SEC61B Gene
Gene ontology Molecular function • protein binding • ribosome binding • poly(A) RNA binding • epidermal growth factor binding Cellular component • endoplasmic reticulum • Sec61 translocon complex • endoplasmic reticulum membrane • cytosol • membrane • integral component of membrane • endoplasmic reticulum Sec complex Biological process • protein import into nucleus, translocation • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • translation • SRP-dependent cotranslational protein targeting to membrane • gene expression • ER-associated ubiquitin-dependent protein catabolic process • endoplasmic reticulum unfolded protein response • retrograde protein transport, ER to cytosol • IRE1-mediated unfolded protein response • antigen processing and presentation of exogenous peptide antigen via MHC class I • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10952	66212
Ensembl	ENSG00000106803	ENSMUSG00000053317
UniProt	P60468	Q9CQS8
RefSeq (mRNA)	NM_006808	NM_024171
RefSeq (protein)	NP_006799	NP_077133
Location (UCSC)	Chr 9: 99.22 – 99.23 Mb	Chr 4: 47.47 – 47.48 Mb
PubMed search

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.^[1][2][3]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.^[3]

References

1. Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851.
2. Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci 112 (10): 1477–86. PMID 10212142.
3. "Entrez Gene: SEC61B Sec61 beta subunit".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (Pt 1): 161–7. PMC 1219334. PMID 9512475.
• Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
• Kalies KU, Rapoport TA, Hartmann E (1998). "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation". J. Cell Biol. 141 (4): 887–94. doi:10.1083/jcb.141.4.887. PMC 2132780. PMID 9585408.
• Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. doi:10.1074/jbc.273.45.29873. PMID 9792704.
• Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919.
• Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation". J. Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC 2168098. PMID 10601334.
• Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature 436 (7048): 290–3. doi:10.1038/nature03670. PMID 16015337.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol. Biol. Cell 18 (3): 1064–72. doi:10.1091/mbc.E06-09-0802. PMC 1805100. PMID 17215517.