SEC61G

Sec61 translocon gamma subunit
Identifiers
Symbols	SEC61G ; SSS1
External IDs	OMIM: 609215 MGI: 1202066 HomoloGene: 40767 GeneCards: SEC61G Gene
Gene ontology Molecular function • protein binding • protein transporter activity • P-P-bond-hydrolysis-driven protein transmembrane transporter activity Cellular component • endoplasmic reticulum membrane • cytosol • membrane • integral component of membrane Biological process • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • translation • SRP-dependent cotranslational protein targeting to membrane • gene expression • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • antigen processing and presentation of exogenous peptide antigen via MHC class I • cellular protein metabolic process • protein targeting to ER • protein transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23480	20335
Ensembl	ENSG00000132432	ENSMUSG00000078974
UniProt	P60059	P60060
RefSeq (mRNA)	NM_001012456	NM_001109971
RefSeq (protein)	NP_001012474	NP_001103441
Location (UCSC)	Chr 7: 54.75 – 54.76 Mb	Chr 11: 16.5 – 16.51 Mb
PubMed search

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.^[1][2][3]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[3]

References

1. Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851.
2. Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci 112 (10): 1477–86. PMID 10212142.
3. "Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading

• Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.". Nature 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469.
• Chen Y, rec F, Le Cahé Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex.". J. Biol. Chem. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.