SECISBP2

SECIS binding protein 2
Identifiers
Symbols	SECISBP2 ; SBP2
External IDs	OMIM: 607693 MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2 Gene
Gene ontology Molecular function • mRNA 3'-UTR binding • protein binding • selenocysteine insertion sequence binding • ribonucleoprotein complex binding • poly(A) RNA binding Cellular component • nucleoplasm • mitochondrion • ribonucleoprotein complex Biological process • selenocysteine incorporation • striatum development • neuron development • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79048	75420
Ensembl	ENSG00000187742	ENSMUSG00000035139
UniProt	Q96T21	Q3U1C4
RefSeq (mRNA)	NM_001282688	NM_001308448
RefSeq (protein)	NP_001269617	NP_001295377
Location (UCSC)	Chr 9: 89.32 – 89.36 Mb	Chr 13: 51.65 – 51.68 Mb
PubMed search

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.^[1][2]

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.^[2]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.^[2]

See also

• Thyroid hormone resistance

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. "Entrez Gene: SECISBP2 SECIS binding protein 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Copeland PR, Fletcher JE, Carlson BA, et al. (2000). "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs". EMBO J. 19 (2): 306–14. doi:10.1093/emboj/19.2.306. PMC 305564. PMID 10637234.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Low SC, Grundner-Culemann E, Harney JW, Berry MJ (2001). "SECIS–SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy". EMBO J. 19 (24): 6882–90. doi:10.1093/emboj/19.24.6882. PMC 305907. PMID 11118223.
• Lescure A, Allmang C, Yamada K, et al. (2002). "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2". Gene 291 (1–2): 279–85. doi:10.1016/S0378-1119(02)00629-7. PMID 12095701.
• Allmang C, Carbon P, Krol A (2002). "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding". RNA 8 (10): 1308–18. doi:10.1017/S1355838202020034. PMC 1370339. PMID 12403468.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Dumitrescu AM, Liao XH, Abdullah MS, et al. (2006). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nat. Genet. 37 (11): 1247–52. doi:10.1038/ng1654. PMID 16228000.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Papp LV, Lu J, Striebel F, et al. (2006). "The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function". Mol. Cell. Biol. 26 (13): 4895–910. doi:10.1128/MCB.02284-05. PMC 1489162. PMID 16782878.