SEMA4C

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Identifiers
Symbols	SEMA4C ; M-SEMA-F; SEMACL1; SEMAF; SEMAI
External IDs	OMIM: 604462 MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C Gene
Gene ontology Molecular function • protein binding Cellular component • extracellular space • postsynaptic density • integral component of membrane • cell junction • synaptic vesicle membrane • postsynaptic membrane Biological process • neural tube closure • cell migration in hindbrain • cerebellum development • positive regulation of stress-activated MAPK cascade • muscle cell differentiation • semaphorin-plexin signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54910	20353
Ensembl	ENSG00000168758	ENSMUSG00000026121
UniProt	Q9C0C4	Q64151
RefSeq (mRNA)	NM_017789	NM_001126047
RefSeq (protein)	NP_060259	NP_001119519
Location (UCSC)	Chr 2: 96.86 – 96.87 Mb	Chr 1: 36.55 – 36.56 Mb
PubMed search

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.^[1][2]

Interactions

SEMA4C has been shown to interact with DLG4.^[3]

References

1. Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
2. "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
3. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Further reading

• Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval.". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
• Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF.". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
• Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95.". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
• Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75.". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.