SEMA5A

Sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Identifiers
Symbols	SEMA5A ; SEMAF; semF
External IDs	OMIM: 609297 MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A Gene
Gene ontology Molecular function • axon guidance receptor activity • semaphorin receptor binding • chondroitin sulfate proteoglycan binding • heparan sulfate proteoglycan binding • syndecan binding Cellular component • plasma membrane • membrane • integral component of membrane • extracellular exosome Biological process • patterning of blood vessels • positive regulation of endothelial cell proliferation • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • cell adhesion • negative regulation of cell adhesion • cell-cell signaling • nervous system development • axon guidance • axonal fasciculation • diencephalon development • positive regulation of actin filament depolymerization • positive regulation of catenin import into nucleus • positive regulation of angiogenesis • positive regulation of axon extension involved in axon guidance • negative regulation of axon extension involved in axon guidance • positive chemotaxis • positive regulation of protein kinase B signaling • cell chemotaxis • signal clustering • negative regulation of endothelial cell apoptotic process • positive regulation of endothelial cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9037	20356
Ensembl	ENSG00000112902	ENSMUSG00000022231
UniProt	Q13591	E9PWW3
RefSeq (mRNA)	NM_003966	NM_009154
RefSeq (protein)	NP_003957	NP_033180
Location (UCSC)	Chr 5: 9.04 – 9.55 Mb	Chr 15: 32.24 – 32.7 Mb
PubMed search

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.^[1][2][3]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]^[3]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (needs citation).

References

1. Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
2. Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
3. "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.". Genome Res. 7 (2): 118–27. doi:10.1101/gr.7.2.118. PMID 9049630.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A.". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism.". Neuropsychobiology 54 (1): 64–9. doi:10.1159/000096040. PMC 2553518. PMID 17028446.