SEPT1
| Septin 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SEPT1 ; DIFF6; LARP; PNUTL3; SEP1 | ||||||||||||
| External IDs | OMIM: 612897 MGI: 1858916 HomoloGene: 23009 GeneCards: SEPT1 Gene | ||||||||||||
| EC number | 3.1.5.1 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1731 | 54204 | |||||||||||
| Ensembl | ENSG00000180096 | ENSMUSG00000000486 | |||||||||||
| UniProt | Q8WYJ6 | P42209 | |||||||||||
| RefSeq (mRNA) | NM_052838 | NM_017461 | |||||||||||
| RefSeq (protein) | NP_443070 | NP_059489 | |||||||||||
| Location (UCSC) |
Chr 16: 30.38 – 30.4 Mb |
Chr 7: 127.21 – 127.22 Mb | |||||||||||
| PubMed search | |||||||||||||
Septin-1 is a protein that in humans is encoded by the SEPT1 gene.[1][2]
Function
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[2]
References
- ↑ Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenet Cell Genet 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
- 1 2 "Entrez Gene: SEPT1 septin 1".
Further reading
- Nottenburg C, Gallatin WM, St John T (1991). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences.". Gene 95 (2): 279–84. doi:10.1016/0378-1119(90)90372-X. PMID 2174398.
- Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease.". Am. J. Pathol. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC 1853406. PMID 9811347.
- Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765.
- Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B.". Biochem. Biophys. Res. Commun. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID 16179162.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (2007). "Overexpression of Septin1: possible contribution to the development of oral cancer.". Int. J. Oncol. 31 (5): 1021–8. doi:10.3892/ijo.31.5.1021. PMID 17912427.
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