SEPT10

Septin 10
Identifiers
Symbol SEPT10
External IDs OMIM: 611737 HomoloGene: 27035 GeneCards: SEPT10 Gene
Orthologs
Species Human Mouse
Entrez 151011 103080
Ensembl ENSG00000186522 ENSMUSG00000019917
UniProt Q9P0V9 Q8C650
RefSeq (mRNA) NM_144710 NM_001024910
RefSeq (protein) NP_653311 NP_001020081
Location (UCSC) Chr 2:
109.54 – 109.61 Mb
Chr 10:
59.16 – 59.22 Mb
PubMed search

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.[1]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.[1]

References

Further reading

  • Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328. 
  • Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217. 
  • Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMID 22320903. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the Sunday, January 31, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.