SEPT10
Septin 10 | |||||||||||||
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Identifiers | |||||||||||||
Symbol | SEPT10 | ||||||||||||
External IDs | OMIM: 611737 HomoloGene: 27035 GeneCards: SEPT10 Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 151011 | 103080 | |||||||||||
Ensembl | ENSG00000186522 | ENSMUSG00000019917 | |||||||||||
UniProt | Q9P0V9 | Q8C650 | |||||||||||
RefSeq (mRNA) | NM_144710 | NM_001024910 | |||||||||||
RefSeq (protein) | NP_653311 | NP_001020081 | |||||||||||
Location (UCSC) |
Chr 2: 109.54 – 109.61 Mb |
Chr 10: 59.16 – 59.22 Mb | |||||||||||
PubMed search | |||||||||||||
Septin 10 is a protein that in humans is encoded by the SEPT10 gene.[1]
Function
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.[1]
References
Further reading
- Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
- Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
- Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMID 22320903.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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