SEPT3

Septin 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3SOP​
Identifiers
Symbols	SEPT3 ; SEP3; bK250D10.3
External IDs	OMIM: 608314 MGI: 1345148 HomoloGene: 99740 GeneCards: SEPT3 Gene
Gene ontology Molecular function • molecular_function • protein binding • GTP binding Cellular component • cytoplasm • cytoskeleton • cell junction • synapse Biological process • cell cycle • cell division Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55964	24050
Ensembl	ENSG00000100167	ENSMUSG00000022456
UniProt	Q9UH03	Q9Z1S5
RefSeq (mRNA)	NM_019106	NM_011889
RefSeq (protein)	NP_061979	NP_036019
Location (UCSC)	Chr 22: 41.98 – 42 Mb	Chr 15: 82.27 – 82.29 Mb
PubMed search

Neuronal-specific septin-3 is a protein that in humans is encoded by the SEPT3 gene.^[1]

Function

This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in multiple transcript variants.^[1]

References

1. "Entrez Gene: SEPT3 septin 3".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Methner A, Leypoldt F, Joost P, Lewerenz J (2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation". Biochem. Biophys. Res. Commun. 283 (1): 48–56. doi:10.1006/bbrc.2001.4741. PMID 11322766.
• Xue J, Milburn PJ, Hanna BT, Graham ME, Rostas JA, Robinson PJ (2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals". Biochem. J. 381 (Pt 3): 753–60. doi:10.1042/BJ20040455. PMC 1133885. PMID 15107017.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Xue J, Tsang CW, Gai WP, Malladi CS, Trimble WS, Rostas JA, Robinson PJ (2005). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals". J. Neurochem. 91 (3): 579–90. doi:10.1111/j.1471-4159.2004.02755.x. PMID 15485489.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.