SEPT4

Septin 4
Identifiers
Symbols	SEPT4 ; ARTS; BRADEION; CE5B3; H5; MART; PNUTL2; SEP4; hCDCREL-2; hucep-7
External IDs	OMIM: 603696 MGI: 1270156 HomoloGene: 6107 GeneCards: SEPT4 Gene
Gene ontology Molecular function • GTPase activity • structural molecule activity • protein binding • GTP binding Cellular component • nucleus • mitochondrion • cytoskeleton • myelin sheath • sperm annulus Biological process • apoptotic process • cell cycle • brain development • sperm mitochondrion organization • positive regulation of protein ubiquitination • regulation of apoptotic process • positive regulation of apoptotic process • sperm capacitation • cell division • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5414	18952
Ensembl	ENSG00000108387	ENSMUSG00000020486
UniProt	O43236	P28661
RefSeq (mRNA)	NM_001198713	NM_001284392
RefSeq (protein)	NP_001185642	NP_001271321
Location (UCSC)	Chr 17: 58.52 – 58.54 Mb	Chr 11: 87.57 – 87.59 Mb
PubMed search

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.^[1][2]

Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[2]

References

1. Paavola P, Horelli-Kuitunen N, Palotie A, Peltonen L (Mar 1999). "Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene". Genomics 55 (1): 122–5. doi:10.1006/geno.1998.5612. PMID 9889007.
2. "Entrez Gene: SEPT4 septin 4".

Further reading

• Xie H, Surka M, Howard J, Trimble WS (1999). "Characterization of the mammalian septin H5: distinct patterns of cytoskeletal and membrane association from other septin proteins.". Cell Motil. Cytoskeleton 43 (1): 52–62. doi:10.1002/(SICI)1097-0169(1999)43:1<52::AID-CM6>3.0.CO;2-5. PMID 10340703.
• Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB (2001). "A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.". Nat. Cell Biol. 2 (12): 915–21. doi:10.1038/35046566. PMID 11146656.
• Zieger B, Tran H, Hainmann I, Wunderle D, Zgaga-Griesz A, Blaser S, Ware J (2001). "Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2.". Gene 261 (2): 197–203. doi:10.1016/S0378-1119(00)00527-8. PMID 11167005.
• Tanaka M, Tanaka T, Kijima H, Itoh J, Matsuda T, Hori S, Yamamoto M (2001). "Characterization of tissue- and cell-type-specific expression of a novel human septin family gene, Bradeion.". Biochem. Biophys. Res. Commun. 286 (3): 547–53. doi:10.1006/bbrc.2001.5413. PMID 11511094.
• Tanaka M, Kijima H, Itoh J, Matsuda T, Tanaka T (2002). "Impaired expression of a human septin family gene Bradeion inhibits the growth and tumorigenesis of colorectal cancer in vitro and in vivo.". Cancer Gene Ther. 9 (6): 483–8. doi:10.1038/sj.cgt.7700460. PMID 12032658.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vega IE, Hsu SC (2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells.". NeuroReport 14 (1): 31–7. doi:10.1097/01.wnr.0000050304.92401.50. PMID 12544826.
• Ihara M, Tomimoto H, Kitayama H, Morioka Y, Akiguchi I, Shibasaki H, Noda M, Kinoshita M (2003). "Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies.". J. Biol. Chem. 278 (26): 24095–102. doi:10.1074/jbc.M301352200. PMID 12695511.
• Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B (2004). "SEPT5_v2 is a parkin-binding protein.". Brain Res. Mol. Brain Res. 117 (2): 179–89. doi:10.1016/S0169-328X(03)00318-8. PMID 14559152.
• Gottfried Y, Rotem A, Lotan R, Steller H, Larisch S (2005). "The mitochondrial ARTS protein promotes apoptosis through targeting XIAP.". EMBO J. 23 (7): 1627–35. doi:10.1038/sj.emboj.7600155. PMC 391065. PMID 15029247.
• Bläser S, Horn J, Würmell P, Bauer H, Strümpell S, Nurden P, Pagenstecher A, Busse A, Wunderle D, Hainmann I, Zieger B (2004). "The novel human platelet septin SEPT8 is an interaction partner of SEPT4.". Thromb. Haemost. 91 (5): 959–66. doi:10.1267/THRO04050959. PMID 15116257.
• Elhasid R, Sahar D, Merling A, Zivony Y, Rotem A, Ben-Arush M, Izraeli S, Bercovich D, Larisch S (2004). "Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients.". Oncogene 23 (32): 5468–75. doi:10.1038/sj.onc.1207725. PMID 15122323.
• Martínez C, Sanjuan MA, Dent JA, Karlsson L, Ware J (2005). "Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.". Biochem. J. 382 (Pt 3): 783–91. doi:10.1042/BJ20040372. PMC 1133953. PMID 15214843.
• Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S (2005). "Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation.". J. Biol. Chem. 280 (27): 25802–10. doi:10.1074/jbc.M501955200. PMID 15837787.
• Lee JW, Soung YH, Young Kim S, Woo Nam S, Sang Park W, Young Lee J, Jin Yoo N, Lee SH (2006). "Mutational analysis of proapoptotic ARTS P-loop domain in common human cancers.". Pathol. Res. Pract. 202 (2): 67–70. doi:10.1016/j.prp.2005.11.001. PMID 16376484.
• Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ, Lee SH (2006). "Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas.". Acta oncologica (Stockholm, Sweden) 45 (1): 101–2. doi:10.1080/02841860500374497. PMID 16464805.
• Garcia W, de Araújo AP, Neto Mde O, Ballestero MR, Polikarpov I, Tanaka M, Tanaka T, Garratt RC (2007). "Dissection of a human septin: definition and characterization of distinct domains within human SEPT4.". Biochemistry 45 (46): 13918–31. doi:10.1021/bi061549z. PMID 17105210.