SEPT7

Septin 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SEPT7 ; CDC10; CDC3; NBLA02942; SEPT7A
External IDs OMIM: 603151 MGI: 1335094 HomoloGene: 1354 GeneCards: SEPT7 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 989 235072
Ensembl ENSG00000122545 ENSMUSG00000001833
UniProt Q16181 O55131
RefSeq (mRNA) NM_001011553 NM_001205367
RefSeq (protein) NP_001011553 NP_001192296
Location (UCSC) Chr 7:
35.8 – 35.91 Mb
Chr 9:
25.25 – 25.31 Mb
PubMed search

Septin-7 is a protein that in humans is encoded by the SEPT7 gene.[1][2]

Function

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.[2]

Interactions

SEPT7 has been shown to interact with SEPT2[3][4] and SEPT9.[4]

References

  1. Nakatsuru S, Sudo K, Nakamura Y (Aug 1994). "Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae". Biochem Biophys Res Commun 202 (1): 82–7. doi:10.1006/bbrc.1994.1896. PMID 8037772.
  2. 1 2 "Entrez Gene: SEPT7 septin 7".
  3. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  4. 1 2 Surka MC, Tsang CW, Trimble WS (Oct 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Mol. Biol. Cell 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755.

Further reading


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