SERTAD1

SERTA domain containing 1
Identifiers
Symbols	SERTAD1 ; SEI1; TRIP-Br1
External IDs	MGI: 1913438 HomoloGene: 8365 GeneCards: SERTAD1 Gene
Gene ontology Molecular function • protein binding Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated • positive regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29950	55942
Ensembl	ENSG00000197019	ENSMUSG00000008384
UniProt	Q9UHV2	Q9JL10
RefSeq (mRNA)	NM_013376	NM_018820
RefSeq (protein)	NP_037508	NP_061290
Location (UCSC)	Chr 19: 40.42 – 40.43 Mb	Chr 7: 27.49 – 27.49 Mb
PubMed search

SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.^[1][2][3]

Interactions

SERTAD1 has been shown to interact with:

• CREB-binding protein,^[4]
• Cyclin-dependent kinase 4,^[2][5] and
• P16.^[2][5]

References

1. Besley GT, Broadhead DM, Lawlor E (Nov 1984). "Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms". J Inherit Metab Dis. 7 Suppl 2: 155–6. doi:10.1007/978-94-009-5612-4_52. PMID 6434876.
2. Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Jan 2000). "Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1". Genes Dev 13 (22): 3027–33. doi:10.1101/gad.13.22.3027. PMC 317153. PMID 10580009.
3. "Entrez Gene: SERTAD1 SERTA domain containing 1".
4. Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (Jun 2003). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
5. Li J, Melvin WS, Tsai MD, Muscarella P (Apr 2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.
• Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (2004). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
• Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU (2004). "The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1". Virology 317 (1): 155–64. doi:10.1016/j.virol.2003.08.008. PMID 14675634.
• Li J, Melvin WS, Tsai MD, Muscarella P (2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.
• Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD (2006). "Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)". Biochemistry 44 (40): 13246–56. doi:10.1021/bi0504658. PMID 16201750.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.