SESN1

Sestrin 1
Identifiers
Symbols	SESN1 ; PA26; SEST1
External IDs	OMIM: 606103 MGI: 2155278 HomoloGene: 8697 GeneCards: SESN1 Gene
Gene ontology Cellular component • nucleus • cytosol Biological process • transcription initiation from RNA polymerase II promoter • cellular response to DNA damage stimulus • cell cycle arrest • negative regulation of cell proliferation • gene expression • regulation of protein kinase B signaling • regulation of response to reactive oxygen species Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27244	140742
Ensembl	ENSG00000080546	ENSMUSG00000038332
UniProt	Q9Y6P5	P58006
RefSeq (mRNA)	NM_001199933	NM_001013370
RefSeq (protein)	NP_001186862	NP_001013388
Location (UCSC)	Chr 6: 108.99 – 109.09 Mb	Chr 10: 41.81 – 41.91 Mb
PubMed search

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene.^[1][2][3]

See also

• SESN2

References

1. "Entrez Gene: sestrin 1".
2. Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10640–4. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
3. Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Budanov AV, Sablina AA, Feinstein E, et al. (2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.". Science 304 (5670): 596–600. doi:10.1126/science.1095569. PMID 15105503.
• Peeters H, Debeer P, Bairoch A, et al. (2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.". Hum. Genet. 112 (5-6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.